지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Treatment-resistant schizophrenia (TRS) has been defined as the persistence of positive symptoms despite two or more trials of antipsychotic medication of adequate dose and duration. TRS is a serious clinical problem and occurs in approximately 30% of patients with schizophrenia. It is important that patients who do not adequately respond to antipsychotics be reevaluated to exclude or address causes other than non-responsiveness to medication, that is, the possibility of pseudo-resistance. In particular, non-adherence to oral antipsychotic treatment should be monitored to rule out pseudo-resistant cases of TRS. Moreover, patients with TRS who take their medication as required may have subtherapeutic antipsychotic plasma levels, secondary to pharmacokinetic factors. In this paper, we review the concept and exclusion of pseudo-resistance, especially owing to non-adherence or pharmacokinetic factors, and present methods to enhance drug adherence.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Howes OD / 2017 / Treatment-resistant schizophrenia : treatment response and resistance in psychosis(TRRIP)working group consensus guidelines on diagnosis and terminology / Am J Psychiatry 174:216~229
Siskind D / 2017 / Clozapine response rates among people with treatment-resistant schizophrenia : data from a systematic review and meta-analysis / Can J Psychiatry 62:772~777
Kane JM / 2019 / Clinical guidance on the identification and management of treatment-resistant schizophrenia / J Clin Psychiatry 80:18com12123
Kinon BJ / 2018 / The group of treatment resistant schizophrenias. heterogeneity in treatment resistant schizophrenia (TRS) / Front Psychiatry 9:757
Potkin SG / 2020 / The neurobiology of treatment-resistant schizophrenia : paths to antipsychotic resistance and a roadmap for future research / NPJ Schizophr 6:1
Siskind D / 2017 / Clozapine response rates among people with treatment-resistant schizophrenia : data from a systematic review and meta-analysis / Can J Psychiatry 62:772~777
Kane JM / 2019 / Clinical guidance on the identification and management of treatment-resistant schizophrenia / J Clin Psychiatry 80:18com12123
Kinon BJ / 2018 / The group of treatment resistant schizophrenias. heterogeneity in treatment resistant schizophrenia (TRS) / Front Psychiatry 9:757
Potkin SG / 2020 / The neurobiology of treatment-resistant schizophrenia : paths to antipsychotic resistance and a roadmap for future research / NPJ Schizophr 6:1
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