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논문 기본 정보

자료유형
학술저널
저자정보
Dominic Andre Staudenmann (AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital Sydney Australia) Ellie Patricia Skacel (The University of Sydney School of Medicine Sydney Australia) Tatiana Tsoutsman (The University of Sydney School of Medicine Sydney Australia) Arthur John Kaffes (The University of Sydney School of Medicine Sydney Australia) Payal Saxena (The University of Sydney School of Medicine Sydney Australia)
저널정보
소화기인터벤션의학회 International Journal of Gastrointestinal Intervention International Journal of Gastrointestinal Intervention 제10권 제3호
발행연도
2021.1
수록면
128 - 132 (5page)

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초록· 키워드

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Background: Five to ten percent of all patients undergoing radiofrequency ablation (RFA), which is the most established technique for Barrett’s esophagus (BE) ablation-develop strictures. Hybrid-argon plasma coagulation (APC) combines APC with submucosal saline injection that was recently developed to tackle this problem. The aims of this pilot study were to evaluate the feasibility, tolerance, safety and long-term efficacy of hybrid-APC for the treatment of BE. Methods: Patients with histological proven BE were selected for hybrid-APC. Prior to APC thermal ablation the mucosa was lifted using a submucosal high-pressure water jet injection system (Erbejet 2; Erbe, Tuebingen, Germany). Short-term (< 48 hours) and long-term (> 48 hours) safety were evaluated. Efficacy of ablation was measured at 3, 6, 12 and 24 months at follow-up endoscopy by evidence of macroscopically complete resolution of BE mucosa and/or histologically complete resolution of intestinal metaplasia (CRIM). Results: Eleven patients were included in the study (average age, 68.2 years; male 72.7%). Eight patients (72.7%) were treatment naive, 9.1% (n = 1) had prior RFA and 18.2% (n = 2) had prior endoscopic mucosal resection. Two patients were excluded from the study. Nine patients (100%) had macroscopic remission and 88.9% (n = 8) had macroscopic remission and microscopic CRIM at 24 months after hybrid-APC ablation. No treatment-related stricture or other major complications were observed, 1 patient (11.1%) reported minor adverse effects. Conclusion: In this prospective pilot study, hybrid-APC appears safe, feasible and effective after 24 months, which has not been evaluated so far. Further large, multi-centre trials are warranted to confirm the present results.
#Argon plasma coagulation #Barrett esophagus #Surgical endoscopy

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참고문헌 (27)

참고문헌 신청
Qumseya B / 2019 / ASGE guideline on screening and surveillance of Barrett’s esophagus / Gastrointest Endosc 90:335~359.e2 google schola Weusten B / 2017 / Endoscopic management of Barrett’s esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement / Endoscopy 49:191~198 google schola Bennett C / 2012 / Consensus statements for management of Barrett’s dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process / Gastroenterology 143:336~346 google schola Ell C / 2000 / Endoscopic mucosal resection of early cancer and high-grade dysplasia in Barrett’s esophagus / Gastroenterology 118:670~677 google schola Sharma P / 2020 / AGA clinical practice update on endoscopic treatment of Barrett’s esophagus with dysplasia and/or early cancer:expert review / Gastroenterology 158:760~769 google schola

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