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논문 기본 정보

자료유형
학술저널
저자정보
정숙향 (서울대학교) 장은선 (서울대학교) 황성호 (수원과학대학교) 김진욱 (서울대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제62권 제1호
발행연도
2021.1
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21 - 28 (8page)

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Purpose: Painful muscle cramps are a common complication in liver cirrhosis patients, and no effective treatment is available. This pilot study aimed to evaluate whether taurine supplementation improves muscle cramps in Korean cirrhotic patients. Materials and Methods: Ten cirrhotic patients who experienced muscle cramps one or more times/week were enrolled in thisprospective single-arm study and administered with an oral taurine solution (1 g/50 mL) thrice a day for 4 weeks. Taurine wasdiscontinued for the subsequent 4 weeks. The frequency and intensity of muscle cramps were evaluated using a questionnaire atweeks 0, 2, 4, 6, and 8 after the start of treatment. Results: At baseline, the median frequency of muscle cramps was six times/week, and all patients had severe pain. Muscle crampscores (frequency×intensity) decreased in seven patients by weeks 4 and 8 after treatment initiation. Compared to baseline musclecramp scores [median 21, interquartile range (IQR): 8?84], median muscle cramp scores were lower at week 4 (6.5, IQR: 3?12,p=0.126) and week 8 (5, IQR: 1.5?56, p=0.066). All five patients whose baseline plasma taurine levels were below the normal limitshowed increased taurine levels at week 4; 60% of them experienced improvements in their muscle cramps. Of the five patientswith normal or higher taurine levels, 80% experienced an improvement in symptoms at week 4. The safety and tolerability of the4-week taurine therapy were excellent. Conclusion: Oral taurine therapy for 4 weeks improved muscle cramps safely in cirrhotic patients.

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