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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,042 - 1,049 (8page)
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초록· 키워드
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Purpose: Malignant gliomas are aggressive spinal cord tumors. In this study, we hypothesized that combination therapy using ananti-angiogenic agent, bevacizumab, and hypoxia-inducible glioblastoma-specific suicide gene could reduce tumor growth. Materials and Methods: In the present study, we evaluated the effect of combination therapy using bevacizumab and pEpo-NI2-SV-TK in reducing the proliferation of C6 cells and tumor growth in the spinal cord. Spinal cord tumor was generated by the injectionof C6 cells into the T5 level of the spinal cord. Complexes of branched polyethylenimine (bPEI)/pEpo-NI2-SV-TK were injectedinto the spinal cord tumor. Bevacizumab was then administered by an intraperitoneal injection at a dose of 7 mg/kg. The anti-cancereffects of combination therapy were analyzed by histological analyses and magnetic resonance imaging (MRI). The Basso, Beattieand Bresnahan scale scores for all of the treatment groups were recorded every other day for 15 days to assess the rat hindlimbstrength. Results: The complexes of bPEI/pEpo-NI2-SV-TK inhibited the viability of C6 cells in the hypoxia condition at 5 days after treatmentwith ganciclovir. Bevacizumab was decreased in the cell viability of human umbilical vein endothelial cells. Combinationtherapy reduced the tumor size by histological analyses and MRI. The combination therapy group showed improved hind-limbfunction compared to the other groups that were administered pEpo-NI2-SV-TK alone or bevacizumab alone. Conclusion: This study suggests that combination therapy using bevacizumab with the pEpo-NI2-SV-TK therapeutic gene couldbe useful for increasing its therapeutic benefits for intramedullary spinal cord tumors.
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참고문헌 (40)
참고문헌 신청
Bakhshi SK / 2016 / Management and outcomes of intramedullary spinal cord tumors : a single center experience from a developing country / Surg Neurol Int 7:S617~S622
Samartzis D / 2015 / Intramedullary spinal cord tumors : part I-epidemiology, pathophysiology, and diagnosis / Global Spine J 5:425~435
Fernandes C / 2017 / Glioblastoma / Codon Publications;
Gwak SJ / 2014 / Effect of combined bevacizumab and temozolomide treatment on intramedullary spinal cord tumor / Spine(Phila Pa 1976) 39:E65~E73
Uei H / 2018 / Clinical results of multidisciplinary therapy including palliative posterior spinal stabilization surgery and postoperative adjuvant therapy for metastatic spinal tumor / J Orthop Surg Res 13:30
Samartzis D / 2015 / Intramedullary spinal cord tumors : part I-epidemiology, pathophysiology, and diagnosis / Global Spine J 5:425~435
Fernandes C / 2017 / Glioblastoma / Codon Publications;
Gwak SJ / 2014 / Effect of combined bevacizumab and temozolomide treatment on intramedullary spinal cord tumor / Spine(Phila Pa 1976) 39:E65~E73
Uei H / 2018 / Clinical results of multidisciplinary therapy including palliative posterior spinal stabilization surgery and postoperative adjuvant therapy for metastatic spinal tumor / J Orthop Surg Res 13:30
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