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논문 기본 정보

자료유형
학술저널
저자정보
박경희 (연세대학교) 심다운 (연세대학교) 이상철 (연세대학교) 문선영 (LG전자) 최은주 (연세대학교) 신혜정 (연세대학교) 김성렬 (연세대학교) 이재현 (연세대학교) 박형호 (LG전자) 허덕 (LG전자) 박중원 (연세대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제8호
발행연도
2020.1
수록면
689 - 697 (9page)

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Purpose: Exposure to particulate matter (PM) is a well-known risk factor in the triggering and exacerbation of allergic airway disease. Indoor environments, where people spend most of their time, are of utmost importance. To assess the effects of air purifiers[equipped with high-efficiency particulate air (HEPA) filters] on allergic rhinitis (AR) in adult patients, we performed a multicenter,randomized, double-blind, and placebo-controlled study. Materials and Methods: Patients with house dust mite (HDM)-induced AR were randomly assigned to either active or mockup(placebo) air-purification groups. Two air purifiers (placed in living room and bedroom) were operated for 6 weeks in each homeenvironment. The primary study endpoint was to achieve improvement in AR symptoms and medication scores. Secondary endpointswere to achieve improvement in the quality of life (QoL) and visual analog scale (VAS) scores, as well as in the indoor (bedroomand living room) concentrations of PM2.5 and PM10. Results: After 6 weeks of air purifier use, medication scores improved significantly in the active (vs. placebo) group, although subjectivemeasures (symptoms, VAS, and QoL scores) did not differ. Bedroom PM2.5 concentrations initially exceeded living room oroutdoor levels, but declined (by up to 51.8%) following active purifier operation. Concentrations of PM2.5 in living room and PM10in bedroom and living room were also significantly reduced through active purification. Conclusion: The use of air purifiers with HEPA filters significantly reduced medication requirements for patients with HDM-inducedAR and significantly lowered indoor PM2.5 concentrations, regardless of room placement. Active intervention to reducehousehold air pollutants may help improve allergic airway disease (clinicaltrials.gov NCT03313453).

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