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논문 기본 정보

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학술저널
저자정보
Owiredu William K. B. A. (Department of Molecular Medicine School of Medicine and Dentistry Kwame Nkrumah University of Scien) Appiah Michael (Department of Molecular Medicine School of Medicine and Dentistry Kwame Nkrumah University of Scien) Obirikorang Christian (Department of Molecular Medicine School of Medicine and Dentistry Kwame Nkrumah University of Scien) Adu Evans Asamoah (Department of Molecular Medicine School of Medicine and Dentistry Kwame Nkrumah University of Scien) Boima Vincent (Department of Medicine and Therapeutics School of Medicine and Dentistry College of Health Sciences) Amos-Abanyie Ernestine Kubi (H3Africa Kidney Disease Research Project Noguchi Memorial Institute for Medical Research University) Akyaw Priscilla Abena (H3Africa Kidney Disease Research Project Noguchi Memorial Institute for Medical Research University) Owiredu Eddie-Williams (Department of Molecular Medicine School of Medicine and Dentistry Kwame Nkrumah University of Scien) Acheampong Emmanuel (School of Medical and Health Science Edith Cowan University Joondalup Australia)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제26권 제4호
발행연도
2020.1
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20 - 28 (9page)

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Background: Chronic kidney disease (CKD) is a significant comorbidity among hypertensive patients. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) have been demonstrated to be significantly associated with CKD, among African- and European-derived populations. We investigated the spectrum of MYH9- associated CKD among Ghanaian hypertensive patients. Methods: The study constituted a total of 264 hypertensive patients. Hypertensive patients with glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 (CKD-EPI formula) or clinically diagnosed were defined as case subjects (n = 132) while those with eGFR ≥60 ml/min/1.73m2 were classified as control subjects (n = 132). Demographic data were obtained with a questionnaire and anthropometric measurements were taken. Five (5) millilitres (ml) of venous blood was drawn from study subjects into gel and EDTA vacutainer tubes. Two (2) mL of EDTA anticoagulated blood was used for genomic DNA extraction while three (3) mL of blood was processed to obtain serum for biochemical measurements. Genotyping of MYH9 polymorphisms (rs3752462) was done employing Tetra primer Amplification Refractory Mutation System (T-ARMS) polymerase chain reaction (PCR). Spot urine samples were also collected for urinalysis. Hardy-Weinberg population was assessed. Logistic regression models were used to assess the associations between single nucleotide polymorphisms and CKD. Results: The cases and control participants differed in terms of age, sex, family history, and duration of CKD (pvalue < 0.001). The minor allele frequencies of rs3752462 SNP were 0.820 and 0.567 respectively among the control and case subjects. Patients with the heterozygote genotype of rs3752462 (CT) were more likely to develop CKD [aOR = 7.82 (3.81?16.04)] whereas those with homozygote recessive variant (TT) were protective [aOR = 0.12 (0.06? 0.25)]. Single nucleotide polymorphism of rs3752462 (CT genotype) was associated with increased proteinuria, albuminuria, and reduced eGFR. Conclusions: We have demonstrated that MYH9 polymorphisms exist among Ghanaian hypertensive patients and rs3752462 polymorphism of MYH9 is associated with CKD. This baseline indicates that further longitudinal and multi-institutional studies in larger cohorts in Ghana are warranted to evaluate MYH9 SNP as an independent predictor of CKD among hypertensive patients in Ghana.
#Chronic kidney disseise #Hypertension #Single nucleotide polymorphism #MYH9- rs3752462

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참고문헌 (31)

참고문헌 신청
Organization WH / 2011 / Political declaration of the High-level Meeting of the General Assembly on the Prevention and Control of Non-communicable Diseases / 66th Session of the Unites Nations General Assembly google schola Organization WH / 2018 / Noncommunicable diseases (NCD) country profiles / Risk of premature death due to NCDS in Ghana google schola Organization WH / 2019 / Hypertension / Global Fact Sheet google schola Barri YM / 2008 / Hypertension and kidney disease : a deadly connection / Curr Hypertens Rep 10(1):39~45 google schola Hamadou B / 2017 / Prevalence and correlates of chronic kidney disease in a group of patients with hypertension in the Savanah zone of Cameroon : a crosssectional study in sub-Saharan Africa / Cardio diagn ther 7(6):581 google schola

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