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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제3호
- 발행연도
- 2021.1
- 수록면
- 347 - 359 (13page)
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Purpose In the present investigation metal (II) complexes containing binuclear Co (II), mono nuclear Ni (II), and Cu (II) with ligand 2E-N-phenyl-2-[([1,3]thiazolo[3,2-a]benzimidazol-2yl) methylidene]hydrazine-1-carbothioamide moiety were synthesized in ethanolic medium, recrystallized and investigated for their biological properties. The carbothioamide was derived from the reaction of benzo [4, 5] imidazo [2, 1-b] thiazole-2-carbaldehyde and 4-phenyl-3-thiosemicarbazide at reflux temperature. Methods The newly formed compounds were characterized by 1H-nuclear magnetic resonance (1H-NMR), 13C-nuclear magnetic resonance (13C-NMR), Fourier transformed infrared spectroscopy (FT-IR), ESR spectroscopic techniques and elemental analysis. Ligand containing “O” and “S” donor atoms participated in coordination with metal (II) complexes and are confirmed by FT-IR, electronic absorption spectra, 1H-NMR data. DNA binding properties of these metal complexes were investigated by ESR, magnetic moments and electronic absorption spectroscopy. Results Antibacterial studies, DNA binding constants of the complexes indicated intercalative binding mode involving strong aromatic chromophoric groups and base pairs of DNA. All the complexes (2a, 2b and 2c) showed intercalative binding with DNA and DNA cleavage was studied in presence and absence of H2O2 which was observed for copper (II) complex. Conclusion Antibacterial study results showed that cobalt complex inhibit the growth of Staphylococcus epidermis, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli with MIC values of 7.98 μg/mL, 8.12 μg/mL, 7.34 μg/mL, and 7.56 μg/mL respectively. Metal (II) complexes exhibit higher antibacterial activity than the parent ligand.
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참고문헌 (54)
참고문헌 신청
Amico JJD / 1966 / US patent 3:225059 / Chem Abstr 64:8193
Bagihalli GB / 2008 / Synthesis, Spectral Characterization, in Vitro Antibacterial, Antifungal and Cytotoxic Activities of Co (II), Ni (II) and Cu(II) Complexes With 1, 2, 4-triazole Schiff Bases / Eur J Med Chem 43(12):2639~2649
Bauer W / 1966 / Antibiotic Susceptibility Testing by a Standardized Single Disk Method / Am J Clin Pathol 45:493~496
Benesi HA / 1949 / A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons / J Am Chem Soc 71(8):2703~2707
Boas JF / 1969 / Electron spin resonance studies of copper (II) hydroxy-carboxylic acid chelates in aqueous and non-aqueous solutions / J Chem Soc (A) :94~108
Bagihalli GB / 2008 / Synthesis, Spectral Characterization, in Vitro Antibacterial, Antifungal and Cytotoxic Activities of Co (II), Ni (II) and Cu(II) Complexes With 1, 2, 4-triazole Schiff Bases / Eur J Med Chem 43(12):2639~2649
Bauer W / 1966 / Antibiotic Susceptibility Testing by a Standardized Single Disk Method / Am J Clin Pathol 45:493~496
Benesi HA / 1949 / A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons / J Am Chem Soc 71(8):2703~2707
Boas JF / 1969 / Electron spin resonance studies of copper (II) hydroxy-carboxylic acid chelates in aqueous and non-aqueous solutions / J Chem Soc (A) :94~108
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