지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 138 - 146 (9page)
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초록· 키워드
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Background: The aryl hydrocarbon receptor (AHR) and autophagy are both important to maintain skin homeostasis. However, they are also involved in skin disorders. So far, their roles in psoriasis pathogenesis are unknown. Objective: We studied the immunohistochemical and gene expression of AHR, CYP1A1, and microtubule-associated protein light chain 3 (LC3) in lesional skin of psoriasis patients to determine correlations among them. Methods: We included 24 psoriasis patients and ten healthy volunteers. Skin biopsies were collected. AHR, CYP1A1, and LC3 protein expression was examined by immunohistochemistry, immunofluorescence, and western blotting. AHR, CYP1A1, LC3, ATG5, BECN1 and Nrf2 mRNA levels were measured by quantitative polymerase chain reaction. Results: AHR and CYP1A1 protein expression were higher in psoriasis lesional skin than in normal skin. LC3 protein expression was lower in psoriasis lesions than in normal controls. AHR and CYP1A1 protein expression in psoriasis lesions showed significant positive correlations with mean epidermal thickness and inflammatory cell density. Significant negative correlations were noted between LC3 protein expression in psoriasis lesions and the mean epidermal thickness or inflammatory cell density. A significant negative correlation was found between AHR and LC3 expression in psoriatic skin. AHR, CYP1A1 and Nrf2 mRNA expression were upregulated while LC3, ATG5, and BECN1 mRNA were down-regulated, in psoriatic lesional skin compared with normal controls. Conclusion: AHR and autophagy could play a role in psoriasis pathogenesis by modifying epidermal hyperproliferation and inflammation. AHR and autophagy regulation are potential therapeutic targets in chronic inflammatory skin diseases.
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참고문헌 (37)
참고문헌 신청
Naldi L / 1999 / Association of early-stage psoriasis with smoking and male alcohol consumption : evidence from an Italian case-control study / Arch Dermatol 135:1479~1484
Gupta MA / 1996 / Cigarette smoking in men may be a risk factor for increased severity of psoriasis of the extremities / Br J Dermatol 135:859~860
Ikuta T / 2009 / AhR protein trafficking and function in the skin / Biochem Pharmacol 77:588~596
Miao W / 2005 / Transcriptional regulation of NF-E2 p45-related factor(NRF2)expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway : direct cross-talk between phase I and II drugmetabolizing enzymes / J Biol Chem 280:20340~20348
Kopf PG / 2010 / 2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1 / Toxicol Appl Pharmacol 245:91~99
Gupta MA / 1996 / Cigarette smoking in men may be a risk factor for increased severity of psoriasis of the extremities / Br J Dermatol 135:859~860
Ikuta T / 2009 / AhR protein trafficking and function in the skin / Biochem Pharmacol 77:588~596
Miao W / 2005 / Transcriptional regulation of NF-E2 p45-related factor(NRF2)expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway : direct cross-talk between phase I and II drugmetabolizing enzymes / J Biol Chem 280:20340~20348
Kopf PG / 2010 / 2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1 / Toxicol Appl Pharmacol 245:91~99
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