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학술저널
저자정보
Arslan Hakan (Department of Endodontics Faculty of Dentistry Health Sciences University Istanbul Turkey.) Yıldız Ezgi Do?anay (Department of Endodontics Faculty of Dentistry Bursa Uludag University Bursa Turkey.) Koseo?lu Serhat (Department of Periodontology Faculty of Dentistry Health Sciences University Istanbul Turkey.)
저널정보
대한치과보존학회 Restorative Dentistry and Endodontics Restorative Dentistry and Endodontics 제45권 제3호
발행연도
2020.1
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1 - 12 (12page)

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Objectives: The aim of this study was to evaluate the effects of endodontic treatment on levels of substance P (SP) and calcitonin gene-related peptide (CGRP) in the saliva of patients with symptomatic apical periodontitis. Materials and Methods: Twelve patients with mandibular molars with symptomatic apical periodontitis were enrolled in this study. An initial saliva sample was collected just before administration of anesthesia for root canal treatment, which was performed at the first visit. A second saliva sample was collected at a control visit 1 week after treatment. Salivary SP and CGRP levels were evaluated quantitatively using biochemical assays. The data were analyzed using Pearson correlation analysis, the paired samples t-test, and the Mann-Whitney U test (p = 0.05). Results: The postoperative salivary level of SP was significantly lower than the preoperative level (p = 0.005). However, the postoperative salivary level of CGRP was similar to the preoperative level (p = 0.932). Visual analog scale (VAS) scores of patients' subjective pain were found to be positively correlated with salivary levels of SP (r = 0.421; p = 0.040). No statistically significant correlations were observed between salivary levels of CGRP and VAS scores for patients' subjective percussion tenderness (p = 0.533) or VAS scores for patients' subjective pain (p = 0.459). Conclusions: According to the results of the present study, salivary SP levels may be used as an objective indicator in the diagnosis and assessment of the degree of pain in endodontic diseases.

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