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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Annis Rakhmawati (Universitas Gadjah Mada) Indera Noor Achmad (Universitas Gadjah Mada) Anggoro Budi Hartopo (Universitas Gadjah Mada) Dyah Wulan Anggrahini (Universitas Gadjah Mada) Irsad Andi Arso (Universitas Gadjah Mada) Noriaki Emoto (Kobe Pharmaceutical University) Lucia Kris Dinarti (Universitas Gadjah Mada)
저널정보
대한재활의학회 Annals of Rehabilitation Medicine Annals of Rehabilitation Medicine 제44권 제6호
발행연도
2020.1
수록면
468 - 480 (13page)

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Objective To assess the effect of combined hospital and home-based exercise programs on functional capacity and quality of life (QoL) among uncorrected atrial septal defect-associated pulmonary arterial hypertension (ASD-PAH) patients. Methods This study was a randomized controlled trial with uncorrected ASD-PAH patients as the subjects. They were allocated randomly into control and exercise groups. Exercise group subjects performed hospital and home-based exercise programs, completing baseline 6-minute walking test (6MWT) and EQ-5D-3L QoL test (Utility Index and EQ-VAS scores), and were followed up for 12 weeks. The primary outcomes were 6MWT distance and EQ-5D-3L score at week 12. The N-terminal pro B-type natriuretic peptide (NT-proBNP) level was also assessed. A repeated-measure ANOVA was performed to detect endpoint differences over time. Results The exercise group contained 20 subjects and control group contained 19. In total, 19 exercise group subjects and 16 control group subjects completed the protocol. The 6MWT distance, Utility Index score, and EQ-VAS score incrementally improved significantly in the exercise group from baseline until week 12, with mean differences of 76.7 m (p<0.001), 0.137 (p<0.001) and 15.5 (p<0.001), respectively. Compared with the control group, the exercise group had significantly increased 6MWT distance and utility index score at week 12. The EQ-VAS score increased in the exercise group at week 12. The NTproBNP level decreased at week 12 in the exercise group. Conclusion Combined hospital and home-based exercise program added to PAH-targeted therapy, improving functional capacity and QoL in uncorrected ASD-PAH patients.
#Heart septal defects #Atrial #Pulmonary arterial hypertension #Exercise therapy #Quality of life #Physical functional performance

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참고문헌 (31)

참고문헌 신청
Lilly SL / 2011 / Pathophysiology of heart disease: a collaborative project of medical students and faculty / Lippincott Williams & Wilkins google schola Galie N / 2016 / 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension : The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology(ESC)and the European Respiratory Society(ERS) : Endorsed by : Association for European Paediatric and Congenital Cardiology(AEPC), International Society for Heart and Lung Transplantation(ISHLT) / Eur Heart J 37:67~119 google schola D’Alto M / 2015 / Pulmonary hypertension related to congenital heart disease : a comprehensive review / Glob Cardiol Sci Pract 2015:42 google schola Dinarti LK / 2020 / The COngenital HeARt Disease in adult and Pulmonary Hypertension(COHARD-PH)registry : a descriptive study from single-center hospital registry of adult congenital heart disease and pulmonary hypertension in Indonesia / BMC Cardiovasc Disord 20:163 google schola Vijarnsorn C / 2018 / Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts / PLoS One 13:e0195092 google schola

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