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논문 기본 정보

자료유형
학술저널
저자정보
Yu So Hyun (Chung-Ang University College of Medicine Seoul Korea) Lee Jeong Hyun (Chung-Ang University College of Medicine Seoul Korea) Kim Min-Chul (Chung-Ang University College of Medicine Seoul KoreaDivision of Infectious Diseases Department of I) Choi Seong-Ho (Chung-Ang University College of Medicine Seoul KoreaDivision of Infectious Diseases Department of I) Chung Jin-Won (Chung-Ang University College of Medicine Seoul KoreaDivision of Infectious Diseases Department of I) Lee Mi-Kyung (Chung-Ang University College of Medicine Seoul KoreaDepartment of Laboratory Medicine Chung-Ang Uni)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제4호
발행연도
2021.1
수록면
386 - 393 (8page)

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Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains were first detected in hospitals in Korea between the late 2000s and early 2010s. However, there is limited information regarding the prevalence of CA-MRSA strains among hospital isolates and their phenotypic changes over the last decade. We investigated the prevalence trend of CA-MRSA strains isolated from different clinical specimens and their phenotypic changes between September 2009 and September 2019. Methods: CA-MRSA strains were phenotypically identified by confirming their resistance to penicillin (PCN) and oxacillin (OXA) and evaluating their susceptibility to trimethoprim-sulfamethoxazole, rifampin, fusidic acid, tetracycline, and at least one of the following four antimicrobials: clindamycin (CLI), erythromycin (ERY), ciprofloxacin (CIP), and gentamicin (GEN). A CA-MRSA strain that exhibited resistance to ERY, CLI, CIP, or GEN was classified as having resistance pattern I, II, III, or IV, respectively, regardless of its resistance to other antimicrobial agents. Results: Of the 8,278 MRSA isolates identified in specimens obtained two days after admission, 1,385 (16.73%) were CA-MRSA strains. The prevalence of CA-MRSA strains increased from 12.2% to 26.6% (3.21% per period, P=0.05). Resistance type analysis revealed an increasing trend in the prevalence of PCN/OXA-resistant (1.84%; P=0.049) and PCN/OXA/ERY/CLI/CIP-resistant (0.98%; P=0.04) CA-MRSA strains and in resistance pattern III strains (2.08%; P=0.004). Conclusions: The prevalence of CA-MRSA strains in Korea has increased significantly over the last decade, and CA-MRSA strains have gained phenotypic diversity beyond PCN/OXA-resistance, including antimicrobial resistance to non-β-lactams, especially CIP.

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