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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호
- 발행연도
- 2021.1
- 수록면
- 239 - 249 (11page)
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The present study explored the therapeutic potential of hydrogen sulfide (H2S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling pathways. The left hind limb was subjected to four short cycles of ischemia and reperfusion (IR) in young and aged male rats to induce RIPC. The hearts were subjected to IR injury on the Langendorff apparatus after 24 h of RIPC. The measurement of lactate dehydrogenase, creatine kinase and cardiac troponin served to assess the myocardial injury. The levels of H2S, cystathionine ?-synthase (CBS), cystathionine ?-lyase (CSE), nuclear factor erythroid 2-related factor 2 (Nrf2), and hypoxia-inducible factor (HIF-1?) were also measured. There was a decrease in cardioprotection in RIPC-subjected old rats in comparison to young rats along with a reduction in the myocardial levels of H2S, CBS, CSE, HIF-1?, and nuclear: cytoplasmic Nrf2 ratio. Supplementation with sodium hydrogen sulfide (NaHS, an H2S donor) and l-cysteine (H2S precursor) restored the cardioprotective actions of RIPC in old hearts. It increased the levels of H2S, HIF-1?, and Nrf2 ratio without affecting CBS and CSE. YC-1 (HIF-1? antagonist) abolished the effects of NaHS and l-cysteine in RIPC-subjected old rats by decreasing the Nrf2 ratio and HIF-1? levels, without altering H2S.The late phase of cardioprotection of RIPC involves an increase in the activity of H2S biosynthetic enzymes, which increases the levels of H2S to upregulate HIF-1? and Nrf2. H2S has the potential to restore aging-induced loss of cardioprotective effects of RIPC by upregulating HIF-1?/Nrf2 signaling.
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참고문헌 (49)
참고문헌 신청
Donato M / 2017 / Protecting the heart from ischemia/reperfusion injury : an update on remote ischemic preconditioning and postconditioning / Curr Opin Cardiol 32:784~790
Singh A / 2017 / Exploring the role of TRPV and CGRP in adenosine preconditioning and remote hind limb preconditioning-induced cardioprotection in rats / Cardiovasc Drugs Ther 31:133~143
Loukogeorgakis SP / 2005 / Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans : role of the autonomic nervous system / J Am Coll Cardiol 46:450~456
Singh H / 2019 / Late phases of cardioprotection during remote ischemic preconditioning and adenosine preconditioning involve activation of neurogenic pathway / J Cardiovasc Pharmacol 73:63~69
Ravingerova T / 2016 / Remote preconditioning as a novel "conditioning" approach to repair the broken heart: potential mechanisms and clinical applications / Physiol Res 65(Suppl 1):S55~S64
Singh A / 2017 / Exploring the role of TRPV and CGRP in adenosine preconditioning and remote hind limb preconditioning-induced cardioprotection in rats / Cardiovasc Drugs Ther 31:133~143
Loukogeorgakis SP / 2005 / Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans : role of the autonomic nervous system / J Am Coll Cardiol 46:450~456
Singh H / 2019 / Late phases of cardioprotection during remote ischemic preconditioning and adenosine preconditioning involve activation of neurogenic pathway / J Cardiovasc Pharmacol 73:63~69
Ravingerova T / 2016 / Remote preconditioning as a novel "conditioning" approach to repair the broken heart: potential mechanisms and clinical applications / Physiol Res 65(Suppl 1):S55~S64
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