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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호
- 발행연도
- 2021.1
- 수록면
- 197 - 206 (10page)
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Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the lineage commitment of mouse bone marrow-derived mesenchymal stem cells (mBMSCs) into osteoblasts and adipocytes. Interestingly, carnosol stimulated the early commitment of mBMSCs into osteoblasts in dose-dependent manner as demonstrated by increased levels of alkaline phosphatase activity and Alizarin red staining for matrix mineralization. On the other hand, carnosol significantly suppressed adipogenesis of mBMSCs and downregulated both early and late markers of adipogenesis. Carnosol showed to induce osteogenesis in a mechanism mediated by activating BMP signaling pathway and subsequently upregulating the expression of BMPs downstream osteogenic target genes. In this context, treatment of mBMSCs with LDN-193189, BMPR1 selective inhibitor showed to abolish the stimulatory effect of carnosol on BMP2-induced osteogenesis. In conclusion, our data identified carnosol as a novel osteoanabolic phytochemical that can promote the differentiation of mBMSCs into osteoblasts versus adipocytes by activating BMP-signaling.
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참고문헌 (40)
참고문헌 신청
Kim JM / 2020 / Osteoblast-osteoclast communication and bone homeostasis / Cells 9:2073
Russow G / 2018 / Anabolic therapies in osteoporosis and bone regeneration / Int J Mol Sci 20:83
Abdallah BM / 2015 / Skeletal(stromal)stem cells : an update on intracellular signaling pathways controlling osteoblast differentiation / Bone 70:28~36
Abdallah BM / 2008 / Human mesenchymal stem cells : from basic biology to clinical applications / Gene Ther 15:109~116
Park-Min KH / 2019 / Metabolic reprogramming in osteoclasts / Semin Immunopathol 41:565~572
Russow G / 2018 / Anabolic therapies in osteoporosis and bone regeneration / Int J Mol Sci 20:83
Abdallah BM / 2015 / Skeletal(stromal)stem cells : an update on intracellular signaling pathways controlling osteoblast differentiation / Bone 70:28~36
Abdallah BM / 2008 / Human mesenchymal stem cells : from basic biology to clinical applications / Gene Ther 15:109~116
Park-Min KH / 2019 / Metabolic reprogramming in osteoclasts / Semin Immunopathol 41:565~572
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