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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호
- 발행연도
- 2021.1
- 수록면
- 189 - 195 (7page)
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Fluoxetine (FLX), a selective serotonin reuptake inhibitor antidepressant, exhibits various other mechanisms of action in numerous cell types and has been shown to induce cell death in cancer cells, paving the way for its potential use in cancer therapy. The aim of this study was to determine the off-target effects of the anti-depressant drug FLX, on the human ovarian granulosa tumor COV434 cells stimulated by forskolin (FSK), by measuring the real-time kinetics of intracellular cyclic AMP (cAMP), ATP level, cytoplasmic calcium ([Ca2+]cyt) and survival of COV434 cells. We show that incubating COV434 cells with FLX (between 0.6 and 10 ?M) induces a decrease in intracellular cAMP response to FSK, a drop in ATP content and stimulates cytoplasmic Ca2+ accumulation in COV434 cells. Only the highest concentrations of FLX (5?10 ?M) diminished cell viability. The present report is the first to identify an action mechanism of FLX in human tumor ovarian cells COV434 cells and thus opening the way to potential use of fluoxetine as a complementary tool, in granulosa tumor treatments.
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참고문헌 (36)
참고문헌 신청
Wong DT / 1995 / Prozac(fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug : twenty years since its first publication / Life Sci 57:411~441
Stark P / 1985 / he pharmacologic profile of fluoxetine / J Clin Psychiatry 46(3 Pt 2):7~13
Fuller RW / 1991 / Fluoxetine, a selective inhibitor of serotonin uptake / Med Res Rev 11:17~34
Pancrazio JJ / 1998 / Inhibition of neuronal Na+ channels by antidepressant drugs / J Pharmacol Exp Ther 284:208~214
Deák F / 2000 / Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells / Neuropharmacology 39:1029~1036
Stark P / 1985 / he pharmacologic profile of fluoxetine / J Clin Psychiatry 46(3 Pt 2):7~13
Fuller RW / 1991 / Fluoxetine, a selective inhibitor of serotonin uptake / Med Res Rev 11:17~34
Pancrazio JJ / 1998 / Inhibition of neuronal Na+ channels by antidepressant drugs / J Pharmacol Exp Ther 284:208~214
Deák F / 2000 / Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells / Neuropharmacology 39:1029~1036
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