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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,120 - 1,134 (15page)
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Purpose Despite advances in treatment, lung cancer remains the leading cause of cancer mortality. This study aimed to characterise genome-wide tumorigenesis events and to understand the hypothesis of the multistep carcinogenesis of lung adenocarcinoma (LUAD) Materials and Methods We conducted multiregion whole-exome sequencing of LUAD with synchronous atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ, or minimally invasive adenocarcinoma of 19 samples from three patients to characterize genome-wide tumorigenesis events and validate the hypothesis of the multistep carcinogenesis of LUAD. We identified potential pathogenic mutations preserved in preinvasive lesions and supplemented the finding by allelic variant level from RNA sequencing. Results Overall, independent mutational profiles were observed per patient and between patients. Some shared mutations including epidermal growth factor receptor (EGFR , p.L858R) were present across synchronous lesions. Conclusion Here, we show that there are driver gene mutations in AAH, and they may exacerbate as a sequence in a histological continuum, supporting the Darwinian evolution model of cancer genome. The intertumoral and intratumoral heterogeneity of synchronous LUAD implies that multi-biomarker strategies might be necessary for appropriate treatment.
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참고문헌 (32)
참고문헌 신청
Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30
Pakkala S / 2018 / Personalized therapy for lung cancer : striking a moving target / JCI Insight 3:e120858
최창민 / 2019 / Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014 / Cancer Research and Treatment 51(4):1400~1410
Zhang J / 2014 / Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing / Science 346:256~259
Travis WD / 2015 / WHO classification of tumours of the lung, pleura, thymus and heart / International Agency for Research on Cancer
Pakkala S / 2018 / Personalized therapy for lung cancer : striking a moving target / JCI Insight 3:e120858
최창민 / 2019 / Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014 / Cancer Research and Treatment 51(4):1400~1410
Zhang J / 2014 / Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing / Science 346:256~259
Travis WD / 2015 / WHO classification of tumours of the lung, pleura, thymus and heart / International Agency for Research on Cancer
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