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논문 기본 정보

자료유형
학술저널
저자정보
Shu-Li Cheng (Department of Nursing Mackay Medical College) Fu-Chi Yang (Department of Neurology Tri-Service General Hospital National Defense Medical Center) Hsuan-Te Chu (Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center) Chia-Kuang Tsai (Department of Neurology Tri-Service General Hospital National Defense Medical Center) Shih-Chieh Ku (Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center) Yu-Ting Tseng (Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center) Ta-Chuan Yeh (Department of Psychiatry Tri-Service General Hospital National Defense Medical Center) Chih-Sung Liang (Department of Psychiatry Beitou Branch Tri-Service General Hospital National Defense Medical Center)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제12호
발행연도
2020.1
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1,191 - 1,199 (9page)

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Objective Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to the pathogenesis of schizophrenia. We aimed to evaluate the effects of a simulated laughter intervention on the levels of cortisol and BDNF and to determine whether the effects associated with simulated laughter could be sustained after discontinuation of the intervention. Methods In this randomized controlled study, patients with schizophrenia according to DSM-IV clinical criteria were randomly assigned to receive either 8-week-long simulated laughter intervention (n=32) or treatment-as-usual group (control group, n=27). The serum levels of BDNF and cortisol were measured at baseline, week 8, and four weeks after discontinuation (week 12) of the intervention program.Results After an 8-week simulated laughter intervention, the laughter group had significantly higher levels of BDNF; however, four weeks after discontinuation of the intervention, the levels of BDNF significantly dropped. Interestingly, the levels of cortisol did not change significantly at week 8, but they were significantly elevated at week 12. The levels of BDNF and cortisol in the control group did not change significantly between week 0 and week 8.Conclusion These findings suggest that the simulated laughter intervention has an early effect on neurogenesis with a significant delayed effect on stress regulation in subjects with schizophrenia.

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