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논문 기본 정보

자료유형
학술저널
저자정보
Hiroya Sakaguchi (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med) Toshitatsu Takao (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med) Yoshitaka Takegawa (KM Biologics Co. Ltd. Kumamoto Japan) Yuki Koga (KM Biologics Co. Ltd. Kumamoto Japan) Kazunori Yamanaka (KM Biologics Co. Ltd. Kumamoto Japan) Masataka Sagata (KM Biologics Co. Ltd. Kumamoto Japan) Shinwa Tanaka (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med) Yoshinori Morita (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med) Takashi Toyonaga (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med) Yuzo Kodama (Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Med)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제1호
발행연도
2021.1
수록면
64 - 72 (9page)

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초록· 키워드

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Background/Aims: Application of polyglycolic acid (PGA) sheets using fibrin glue in post-endoscopic submucosal dissection (ESD)ulcers to prevent bleeding has been reported to be difficult with the conventional delivery method because of gravity. This studyassessed the usefulness of the envelope-based delivery system with and against gravity in living pigs. Methods: PGA sheets were applied on post-ESD ulcers with and against gravity six times each using the conventional and envelopemethods, respectively. The PGA sheet delivery time and the endoscopic and histological findings of the treated ulcer floors werecompared. Results: With gravity, the median PGA sheet application time was 1.00 (0.68?1.30) min/cm2 and 0.32 (0.18?0.52) min/cm2 with theconventional and envelope techniques (p=0.002), respectively, and against gravity, it was 1.20 (1.13?1.63) min/cm2 and 0.50 (0.39?0.58) min/cm2 (p=0.002), respectively. Against gravity, the endoscopic and histological findings revealed that the conventional grouphad insufficient fixation of the PGA sheets, but the envelope groups had sufficient fixation. The results with gravity were similarbetween the groups. Conclusions: The envelope method makes it possible to deliver PGA sheets to the stomach quickly and cover ulcers appropriatelyboth with and against gravity in living pigs.
#Endoscopic submucosal dissection #Fibrin tissue adhesive #Gastrointestinal hemorrhage #Polyglycolic acid #Stomach

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참고문헌 (22)

참고문헌 신청
Oda I / 2013 / Complications of gastric endoscopic submucosal dissection / Dig Endosc 25(Suppl 1):71~78 google schola Kataoka Y / 2016 / Bleeding after endoscopic submucosal dissection : risk factors and preventive methods / World J Gastroenterol 22:5927~5935 google schola Sato C / 2017 / Postoperative bleeding in patients on antithrombotic therapy after gastric endoscopic submucosal dissection / World J Gastroenterol 23:5557~5566 google schola Oda I / 2015 / Is there a need to shield ulcers after endoscopic submucosal dissection in the gastrointestinal tract? / Endosc Int Open 3:E152~E153 google schola Kawata N / 2018 / Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents / Gastric Cancer 21:696~702 google schola

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