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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 332 - 338 (7page)
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초록· 키워드
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Background: Previous studies have shown that body composition is associated with chronic kidney disease (CKD), and perimenopause is associated with increased fat mass and decreased lean body mass. Muscle wasting is common among patients with CKD. Sarcopenic obesity (SO) refers to excess adiposity with decreased muscle mass. However, little is known about the relationship between SO and renal function decline. Here, we identified the relationship between SO and decreased estimated glomerular filtration rate (eGFR) in postmenopausal women. Methods: We conducted a cross-sectional study based on the data from the Korea National Health and Nutrition Examination Survey (2008?2011). We analyzed 4,560 postmenopausal women who underwent dual energy X-ray absorptiometry. Sarcopenia was defined based on weight-adjusted appendicular skeletal muscle mass. Obesity was defined based on body mass index. The eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Subjects were classified into four groups: normal, obese, sarcopenic, and sarcopenic obese. Logistic regression analysis was performed to examine the association between SO and decreased eGFR. The results were adjusted for variable confounders. Results: In the unadjusted model, the odds ratio (OR) of decreased eGFR for SO was 1.67 (95% confidence interval [CI], 1.23?2.26). The obese and sarcopenic groups had ORs of 0.67 (95% CI, 0.44?1.03) and 0.70 (95% CI, 0.44?1.10), respectively. After controlling for confounding variables, there was also a significant association between SO and decreased eGFR (adjusted OR, 1.48; 95% Cl, 1.05?2.07). Conclusion: SO was independently associated with decreased eGFR in postmenopausal Korean women.
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참고문헌 (31)
참고문헌 신청
Chen J / 2004 / The metabolic syndrome and chronic kidney disease in U. S. adults / Ann Intern Med 140:167~174
Chronic Kidney Disease Prognosis Consortium / 2010 / Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts : a collaborative meta-analysis / Lancet 375:2073~2081
Coresh J / 2007 / Prevalence of chronic kidney disease in the United States / JAMA 298:2038~2047
황은아 / 2015 / Management of chronic kidney disease–mineral and bone disorder: Korean working group recommendations / Kidney Research and Clinical Practice 34(1):4~12
Hernandez HJ / 2018 / Physical therapy considerations for chronic kidney disease and secondary sarcopenia / J Funct Morphol Kinesiol 3:5
Chronic Kidney Disease Prognosis Consortium / 2010 / Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts : a collaborative meta-analysis / Lancet 375:2073~2081
Coresh J / 2007 / Prevalence of chronic kidney disease in the United States / JAMA 298:2038~2047
황은아 / 2015 / Management of chronic kidney disease–mineral and bone disorder: Korean working group recommendations / Kidney Research and Clinical Practice 34(1):4~12
Hernandez HJ / 2018 / Physical therapy considerations for chronic kidney disease and secondary sarcopenia / J Funct Morphol Kinesiol 3:5
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