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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 539 - 546 (8page)
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초록· 키워드
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Hibiscus syriacus (H. syriacus), which belongs to Malvaceae, is a perennial herb widely distributed in East Asia. In this study, we investigated the anti-infammatory efects and its potential molecular mechanisms of leaves extracted with 70% ethanol of H. syriacus (HS-L) at the mRNA and protein level when RAW264.7 macrophages were stimulated by LPS. HS-L dose dependently (0, 25, 50, 100?μg/mL) reduced NO production by inhibiting iNOS, COX-2, and IL-β expression in LPS?induced RAW264.7 macrophages. HS-L decreased the LPS-stimulated degradation and phosphorylation of IkB-a. Moreover, treatment with HS-L suppressed LPS-induced DNA binding of NF-kB and nuclear translocation of p65. Furthermore, HS-L suppressed the phosphorylation of ERK1/2 and p38. HS-L was analyzed to contain compounds such as 2-pentadecanone, methyl palmitate, and ethyl palmitate in GC/MS analysis. These results suggested that HS-L could utilize anti-infammatory activity by inhibiting NF-κB and MAPKs signaling pathways and that HS-L could be used as a natural anti-infammatory agent.
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참고문헌 (25)
참고문헌 신청
안승규 / 2014 / 한약추출 부산물의 영양가치 평가와 항산화 효능에 관한 연구 / 농업생명과학연구 48(2):101~110
최다희 / 2018 / RAW264.7 대식세포에서 MAPK 및 NF-κB 신호전달 억제를 통한 rebaudioside A의 항염 효과 / Journal of Applied Biological Chemistry 61(2):205~211
El-Demerdash E / 2011 / Anti-inflammatory and antifibrotic effects of methyl palmitate / Toxicol Appl Pharmacol 254:238~244
Hsu RJ / 2015 / The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells / BMC Complement Altern Med 15:65~74
장아람 / 2012 / 무궁화 (Hibiscus syriacus) 추출물의 화장품 생리 및 피부세포 활성 연구
최다희 / 2018 / RAW264.7 대식세포에서 MAPK 및 NF-κB 신호전달 억제를 통한 rebaudioside A의 항염 효과 / Journal of Applied Biological Chemistry 61(2):205~211
El-Demerdash E / 2011 / Anti-inflammatory and antifibrotic effects of methyl palmitate / Toxicol Appl Pharmacol 254:238~244
Hsu RJ / 2015 / The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells / BMC Complement Altern Med 15:65~74
장아람 / 2012 / 무궁화 (Hibiscus syriacus) 추출물의 화장품 생리 및 피부세포 활성 연구
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