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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제11호
- 발행연도
- 2020.1
- 수록면
- 1,614 - 1,625 (12page)
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초록· 키워드
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A number of species of the genus Trichilia (Meliaceae) exhibit anti-inflammatory effects. However, the effect of Trichilia martiana C. DC. (TM) on lipopolysaccharide (LPS)-induced inflammation has not, to the best of our knowledge, yet been determined. Therefore, in the present study, the antiinflammatory effect of TM on LPS-stimulated RAW264.7 macrophages was evaluated. The ethanol extract of TM (TMEE) significantly inhibited LPS-induced nitric oxide (NO), prostaglandin 2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). TMEE also reduced the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL- 6. The upregulation of mitogen-activated protein kinases (MAPKs) and NF-κB activation was revealed to be downregulated following TMEE pretreatment. Furthermore, TMEE was indicated to lead to the nucleus translocation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and the expression of heme oxygenase-1 (HO-1). In H292 airway epithelial cells, the pretreatment of TMEE significantly downregulated the production of LPS-stimulated IL-1β, and TMEE was indicated to increase the expression of HO-1. In animal models exhibiting LPS-induced acute lung injury (ALI), treatment with TMEE reduced the levels of macrophages influx and TNF-α production in the bronchoalveolar lavage fluid (BALF) of ALI mice. Additionally, TMEE significantly downregulated the activation of ERK, JNK and IκB, and upregulated the expression of HO-1 in the lungs of ALI mice. In conclusion, the results of the current study demonstrated that TMEE could exert a regulatory role in the prevention or treatment of the endotoxin-mediated inflammatory response.
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참고문헌 (35)
참고문헌 신청
Lee JW / 2014 / 3, 4, 5-trihydroxycinnamic acid inhibits lipopolysaccharide(LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo / Mol. Cell. Biochem 390:143~153
Lee JW / 2018 / Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury / J. Ethnopharmacol. 210:23~30
Jiang L / 2019 / GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation / Pulm. Pharmacol. Ther 54:77~86
Zhang Y / 2019 / MCP-induced protein 1 attenuates sepsis-induced acute lung injury by modulating macrophage polarization via the JNK/c-Myc pathway / Int. Immunopharmacol 75:105741
Khan A / 2019 / Anomalin attenuates LPS-induced acute lungs injury through inhibition of AP-1 signaling / Int. Immunopharmacol 73:451~460
Lee JW / 2018 / Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury / J. Ethnopharmacol. 210:23~30
Jiang L / 2019 / GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation / Pulm. Pharmacol. Ther 54:77~86
Zhang Y / 2019 / MCP-induced protein 1 attenuates sepsis-induced acute lung injury by modulating macrophage polarization via the JNK/c-Myc pathway / Int. Immunopharmacol 75:105741
Khan A / 2019 / Anomalin attenuates LPS-induced acute lungs injury through inhibition of AP-1 signaling / Int. Immunopharmacol 73:451~460
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