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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제8호
- 발행연도
- 2020.1
- 수록면
- 1,214 - 1,221 (8page)
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초록· 키워드
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Esculetin 6-O-β-D-arabinofuranosyl-(1 →6)-β-D-glucopyranoside (EAG) is a coumarin glycoside isolated from the stem bark of Fraxinus rhynchophylla. This study scrutinized the anti-proliferative activity of EAG on blood cancer-derived Jurkat leukemic cells. Cell viability assays in leukemic cancer cells determined that EAG possesses potent anti-proliferative effects. Moreover, treatment with EAG increased the proportion of apoptotic cells, resulted in cell cycle arrest being induced at the subG0/ G1 phase, and reduced the proportion of cells present in the S phase. In addition, mitochondrial membrane potential was reduced by EAG in Jurkat cells. Additionally, EAG triggered apoptosis that was mediated by the downregulation of BCL-XL, p-IκBα, and p-p65 expressions in addition to the upregulation of cleaved Caspase 3 and BAX expressions. These findings revealed that the toxic effect of EAG was mediated by intracellular signal transduction pathways that involved a mechanism in which reactive oxygen species (ROS) were upregulated. Thus, this study concludes that EAG could potentially serve as a therapeutic agent for leukemia.
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참고문헌 (30)
참고문헌 신청
Aoyama Y / 1992 / A new antitumor antibiotic product, demethylchartreusin isolation and biological activities / J. Antibiot. (Tokyo) 45:875~878
Asghar U / 2015 / The history and future of targeting cyclin-dependent kinases in cancer therapy / Nat. Rev. Drug Discov 14:130~146
Castillo JJ / 2012 / Obesity but not overweight increases the incidence and mortality of leukemia in adults : a meta-analysis of prospective cohort studies / Leuk. Res 36:868~875
Chang JC / 2019 / Intermittent hypoxia prevents myocardial mitochondrial Ca2+overload and cell death during Ischemia/Reperfusion : the role of reactive oxygen species / Cells 8:564
Cragg GM / 2013 / Natural products : A continuing source of novel drug leads / Biochim. Biophys. Acta Gen. Subj 1830:3670~3695
Asghar U / 2015 / The history and future of targeting cyclin-dependent kinases in cancer therapy / Nat. Rev. Drug Discov 14:130~146
Castillo JJ / 2012 / Obesity but not overweight increases the incidence and mortality of leukemia in adults : a meta-analysis of prospective cohort studies / Leuk. Res 36:868~875
Chang JC / 2019 / Intermittent hypoxia prevents myocardial mitochondrial Ca2+overload and cell death during Ischemia/Reperfusion : the role of reactive oxygen species / Cells 8:564
Cragg GM / 2013 / Natural products : A continuing source of novel drug leads / Biochim. Biophys. Acta Gen. Subj 1830:3670~3695
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