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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 804 - 812 (9page)
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초록· 키워드
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In cells, proteins form macromolecular complexes to execute their own unique roles in biological processes. Conventional structural biology methods adopt a bottom-up approach starting from defined sets of proteins to investigate the structures and interactions of protein complexes. However, this approach does not reflect the diverse and complex landscape of endogenous molecular architectures. Here, we introduce a top-down approach called Electron Microscopy screening for endogenous Protein ArchitectureS (EMPAS) to investigate the diverse and complex landscape of endogenous macromolecular architectures in an unbiased manner. By applying EMPAS, we discovered a spiral architecture and identified it as AdhE. Furthermore, we performed screening to examine endogenous molecular architectures of human embryonic stem cells (hESCs), mouse brains, cyanobacteria and plant leaves, revealing their diverse repertoires of molecular architectures. This study suggests that EMPAS may serve as a tool to investigate the molecular architectures of endogenous macromolecular proteins.
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참고문헌 (21)
참고문헌 신청
Ahn, S. / 2004 / Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor / J. Biol. Chem 279:35518~35525
Burley, S. K. / 2000 / An overview of structural genomics / Nat. Struct. Biol. 7(Suppl):932~934
Burley, S. K. / 2017 / Protein Data Bank(PDB) : the single global macromolecular structure archive / Methods Mol. Biol 1607:627~641
Collins, B. C. / 2013 / Quantifying protein interaction dynamics by SWATH mass spectrometry : application to the 14-3-3system / Nat. Methods 10:1246~1253
Grabowski, M. / 2016 / The impact of structural genomics : the first quindecennial / J. Struct. Funct. Genomics 17:1~16
Burley, S. K. / 2000 / An overview of structural genomics / Nat. Struct. Biol. 7(Suppl):932~934
Burley, S. K. / 2017 / Protein Data Bank(PDB) : the single global macromolecular structure archive / Methods Mol. Biol 1607:627~641
Collins, B. C. / 2013 / Quantifying protein interaction dynamics by SWATH mass spectrometry : application to the 14-3-3system / Nat. Methods 10:1246~1253
Grabowski, M. / 2016 / The impact of structural genomics : the first quindecennial / J. Struct. Funct. Genomics 17:1~16
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