지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 266 - 271 (6page)
이용수
초록· 키워드
오류제보하기
Estrogen-related receptor γ (ERRγ), a member of the orphan nuclear receptor family, is a key mediator in cellular metabolic processes and energy homeostasis. Therefore, ERRγ has become an attractive target for treating diverse metabolic disorders. We recently reported that ERRγ acts as a negative regulator of osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand (RANKL). In the present study, we explored the effects of an ERRγ-specific modulator, GSK5182, on ERRγ-regulated osteoclast differentiation and survival. Interestingly, GSK5182 increased ERRγ protein levels much as does GSK4716, which is an ERRγ agonist. GSK5182 inhibited osteoclast generation from bone-marrow-derived macrophages without affecting cytotoxicity. GSK5182 also attenuated RANKL-mediated expression of c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), pivotal transcription factors for osteoclastogenesis. Arrested osteoclast differentiation was associated with reduced RANK expression, but not with the M-CSF receptor, c-Fms. GSK5182 strongly blocked the phosphorylation of IκBα, c-Jun N-terminal kinase, and extracellular signal-regulated kinase in response to RANKL. GSK5182 also suppressed NF-κB promoter activity in a dose-dependent manner. In addition to osteoclastogenesis, GSK5182 accelerated osteoclast apoptosis by caspase-3 activation. Together, these results suggest that GSK5182, a synthetic ERRγ modulator, may have potential in treating disorders related to bone resorption.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Teitelbaum SL / 2000 / Bone resorption by osteoclasts / Science 289:1504~1508
Tsukasaki M / 2019 / Osteoimmunology : evolving concepts in bone-immune interactions in health and disease / Nat Rev Immunol 19:626~642
Kong YY / 1999 / OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis / Nature 397:315~323
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165~176
Teitelbaum SL / 2000 / Bone resorption by osteoclasts / Science 289:1504~1508
Tsukasaki M / 2019 / Osteoimmunology : evolving concepts in bone-immune interactions in health and disease / Nat Rev Immunol 19:626~642
Kong YY / 1999 / OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis / Nature 397:315~323
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165~176
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27
Experimental and Molecular Medicine
2016 .01
-
Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis
BMB Reports
2018 .01
-
Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases
Experimental and Molecular Medicine
2024 .02
-
Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3
BMB Reports
2016 .01
-
SU-8 Inhibit Osteoclast Differentiation by downregulating NFATc1
한국생물공학회 학술대회
2017 .10
-
AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과
KSBB Journal
2018 .12
-
Effects of microRNA-135a on the epithelial–mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3β through the Wnt/β-catenin signaling pathway
Experimental and Molecular Medicine
2018 .01
-
Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways
BMB Reports
2017 .01
-
Dehydrocostus lactone inhibits NFATc1 via regulation of IKK, JNK, and Nrf2, thereby attenuating osteoclastogenesis
BMB Reports
2020 .01
-
Serum amyloid A inhibits RANKL-induced osteoclast formation
Experimental and Molecular Medicine
2015 .01
-
Extracts from Cnidium monnieri (L.) Cusson Induces Apoptosis and G1 Cell Cycle Arrest through Reducing COX-2 Expression by Regulating the Akt/GSK-3β Signaling Pathways
KSBB Journal
2023 .06
-
Apoptosis effects of extract from Allium hookeri by AMPK/ Akt/ GSK-3β signal pathway in AGS Gastric Cancer Cells
한국생물공학회 학술대회
2018 .04
-
Spi-C positively regulates RANKL-mediated osteoclast differentiation and function
Experimental and Molecular Medicine
2020 .01
-
Remifentanil Negatively Regulates RANKL-Induced Osteoclast Differentiation and Bone Resorption by Inhibiting c-Fos/NFATc1 Expression
조직공학과 재생의학
2018 .01
-
Tusc2/Fus1 regulates osteoclast differentiation through NF-kB and NFATc1
BMB Reports
2017 .01
-
Adipose Tissue-Derived Mesenchymal Stem Cell Inhibits Osteoclast Differentiation through Tumor Necrosis Factor Stimulated Gene-6
조직공학과 재생의학
2024 .06
-
PyP-R13-6 Inhibits Osteoclast Differentiation In vitro and In vivo
한국생물공학회 학술대회
2017 .04
-
Glycogen synthase kinase 3β in Toll-like receptor signaling
BMB Reports
2016 .01
-
Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability
Experimental and Molecular Medicine
2022 .08
-
IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
BMB Reports
2021 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0