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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 482 - 487 (6page)
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Interferon regulatory factors (IRFs) play roles in various biologicalprocesses including cytokine signaling, cell growth regulationand hematopoietic development. Although it has beenreported that several IRFs are involved in bone metabolism,the role of IRF2 in bone cells has not been elucidated. Here,we investigated the involvement of IRF2 in RANKL-inducedosteoclast differentiation. IRF2 overexpression in osteoclast precursorcells enhanced osteoclast differentiation by regulatingthe expression of NFATc1, a master regulator of osteoclastogenesis.
Conversely, IRF2 knockdown inhibited osteoclast differentiationand decreased the NFATc1 expression. Moreover, IRF2increased the translocation of NF-κB subunit p65 to the nucleusin response to RANKL and subsequently induced the expressionof NFATc1. IRF2 plays an important role in RANKL-inducedosteoclast differentiation by regulating NF-κB/NFATc1 signalingpathway. Taken together, we demonstrated the molecular mechanismof IRF2 in osteoclast differentiation, and provide a molecularbasis for potential therapeutic targets for the treatment ofbone diseases characterized by excessive bone resorption.
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참고문헌 (33)
참고문헌 신청
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
김정하 / 2014 / Regulation of NFATc1 in Osteoclast Differentiation / 대한골대사학회지 21(4):233~241
김정하 / 2016 / Signaling Pathways in Osteoclast Differentiation / 전남의대학술지 52(1):12~17
Asagiri M / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis / J Exp Med 202:1261~1269
Takayanagi H / 2002 / Induction and activation of the transcription factor NFATc1(NFAT2)integrate RANKL signaling in terminal differentiation of osteoclasts / Dev Cell 3:889~901
김정하 / 2014 / Regulation of NFATc1 in Osteoclast Differentiation / 대한골대사학회지 21(4):233~241
김정하 / 2016 / Signaling Pathways in Osteoclast Differentiation / 전남의대학술지 52(1):12~17
Asagiri M / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis / J Exp Med 202:1261~1269
Takayanagi H / 2002 / Induction and activation of the transcription factor NFATc1(NFAT2)integrate RANKL signaling in terminal differentiation of osteoclasts / Dev Cell 3:889~901
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