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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제1호
- 발행연도
- 2021.1
- 수록면
- 81 - 89 (9page)
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Purpose: A steady increase in Clostridioides difficile enteritis (CDE) has been reported recently. CDE is associated with intestinal dysbiosis, and vitamin D receptors are known to play an important role in this microbial imbalance as immunological regulators. We investigated the difference in vitamin D levels between children with CDE and those with other acute infectious enteritis. Methods: This retrospective study was conducted on children below 18 years of age who visited the Gil hospital, underwent investigation to assess vitamin D levels, and had confirmed gastrointestinal infection between January 2015 and December 2018. Patients were divided into two groups: the “CDE group” (n=18) and the “other infectious enteritis group” (n=88); their clinical characteristics, other laboratory results, and vitamin D levels were analyzed. Results: There was no difference in gender, age, and seasonal distributions between the CDE and other infectious enteritis groups. Other laboratory results were not significantly different between two groups, excluding serum albumin level (4.52±0.45 g/dL vs. 4.31±0.28 g/dL, p=0.011). The mean 25-hydroxy vitamin D level in the CDE group was higher than that in the control group (18.75±8.11 ng/mL vs. 14.50±6.79 ng/mL, p=0.021). Conclusion: Vitamin D levels in the CDE group were lower than normal but higher than the other infectious enteritis group. These results suggested that CDE has a different mechanism or susceptibility associated with vitamin D in children, and even marginal changes in vitamin D levels can act as a risk factor for infection.
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참고문헌 (24)
참고문헌 신청
Cózar-Llistó A / 2016 / Clostridium difficile infection in special high-risk populations / Infect Dis Ther 5:253~269
Lamont JT / 2002 / Woodward Award. How bacterial enterotoxins work: insights from in vivo studies / Trans Am Clin Climatol Assoc 113:167~180
Migriauli I / 2018 / Epidemiology of Clostridium difficile infection in hospitalised pediatric patients in Georgia / Georgian Med News :172~176
Jangi S / 2010 / Asymptomatic colonization by Clostridium difficile in infants : implications for disease in later life / J Pediatr Gastroenterol Nutr 51:2~7
McFarland LV / 2016 / Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections / World J Gastroenterol 22:3078~3104
Lamont JT / 2002 / Woodward Award. How bacterial enterotoxins work: insights from in vivo studies / Trans Am Clin Climatol Assoc 113:167~180
Migriauli I / 2018 / Epidemiology of Clostridium difficile infection in hospitalised pediatric patients in Georgia / Georgian Med News :172~176
Jangi S / 2010 / Asymptomatic colonization by Clostridium difficile in infants : implications for disease in later life / J Pediatr Gastroenterol Nutr 51:2~7
McFarland LV / 2016 / Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections / World J Gastroenterol 22:3078~3104
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