지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제6호
- 발행연도
- 2020.1
- 수록면
- 539 - 547 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Pediatric acute liver failure (PALF) is a serious condition; however, data on PALF in developing countries are sparse, particularly concerning molecular diagnosis and liver transplantation (LT). This study aimed to determine the causes, outcomes, and prognostic factors of PALF. Methods: We retrospectively reviewed the medical records of children (age <15 years) with PALF diagnosed using the American Association for the Study of Liver Diseases criteria at our center from 2011 to 2016. The collected data included laboratory results, complications, outcomes, and potential factors associated with death and LT. Results: We included a total of 27 patients, with a median age of 2 years (interquartile range, 3 months to 4 years). Viral infection was the most common etiology (n=8, 30%), predominantly dengue infection (n=4). A total of 16 patients (59%) died and 11 patients survived (3 patients with LT). The prognostic factors associated with death or LT requirement were grade IV hepatic encephalopathy (p<0.01), hypotension (p=0.02), gastrointestinal bleeding (p=0.03), increased intracranial pressure (p=0.04), and higher peak serum lactate level (p=0.01). Peak serum lactate ≥6 mmoL/L had a sensitivity of 79% and a specificity of 88% for predicting mortality or the necessity of LT. Conclusion: Viral infection was the most common cause of PALF. The mortality rate remained high, and a considerable number of patients required LT. In addition to several clinical factors, peak serum lactate could be a potential marker for predicting poor outcomes in PALF.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Mouzaki M / 2010 / Acute liver failure in children / Clin Pediatr Emerg Med 11:198~206
Squires RH Jr / 2006 / Acute liver failure in children : the first 348 patients in the pediatric acute liver failure study group / J Pediatr 148:652~658
Arora NK / 1996 / Acute viral hepatitis types E, A, and B singly and in combination in acute liver failure in children in north India / J Med Virol 48:215~221
Escorsell A / 2007 / Acute liver failure in Spain: analysis of 267 cases / Liver Transpl 13:1389~1395
Durand P / 2001 / Acute liver failure in infancy : a 14-year experience of a pediatric liver transplantation center / J Pediatr 139:871~876
Squires RH Jr / 2006 / Acute liver failure in children : the first 348 patients in the pediatric acute liver failure study group / J Pediatr 148:652~658
Arora NK / 1996 / Acute viral hepatitis types E, A, and B singly and in combination in acute liver failure in children in north India / J Med Virol 48:215~221
Escorsell A / 2007 / Acute liver failure in Spain: analysis of 267 cases / Liver Transpl 13:1389~1395
Durand P / 2001 / Acute liver failure in infancy : a 14-year experience of a pediatric liver transplantation center / J Pediatr 139:871~876
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