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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background and Purpose Long-term changes in post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and post-stroke anger (PSA) have rarely been studied. Methods This is a sub-study of EMOTION, a randomized, placebo-controlled trial, that examined the efficacy of escitalopram on PSD, PSEI, and PSA in patients with stroke. We interviewed patients at the long-term period (LTP) using predefined questionnaires: Montgomery-Asberg depression rating scale (MADRS) for PSD, modified Kim’s criteria for PSEI, and Spielberger trait anger scale for PSA. Additionally, the ENRICHD Social Support Instrument (ESSI) for the social support state and the modified Rankin Scale (mRS) were measured. We investigated the changes in and factors behind PSD, PSEI, and PSA at LTP. Results A total of 222 patients were included, and the median follow-up duration was 59.5 months (interquartile range, 50 to 70). Compared to the data at 6 months post-stroke, the prevalence of PSEI (11.7% at 6 months, 6.3% at LTP; P=0.05) and mean anger score (21.62, 16.24; P<0.01) decreased, while the prevalence of PSD (35.6%, 44.6%; P=0.03) and mean MADRS (6.16, 8.67; P<0.01) increased at LTP. ESSI was associated with PSD and PSA, but not with PSEI. The effect of the baseline National Institutes of Health Stroke Scale score on PSD decreased over time. The effect of low social support on PSD was greater than that of mRS at LTP. Conclusions The prevalence and degree of PSD significantly increased, while those of PSEI and PSA decreased at LTP. PSD in this stage appeared to be more closely associated with a lack of social support than patients' physical disabilities.
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참고문헌 (29)
참고문헌 신청
Kim JS / 2002 / Inability to control anger or aggression after stroke / Neurology 58:1106~1108
Kim JS / 2000 / Poststroke depression and emotional incontinence : correlation with lesion location / Neurology 54:1805~1810
Jong S. Kim / 2016 / Post-stroke Mood and Emotional Disturbances: Pharmacological Therapy Based on Mechanisms / 대한뇌졸중학회지 18(3):244~255
Hackett ML / 2014 / Part I : frequency of depression after stroke : an updated systematic review and meta-analysis of observational studies / Int J Stroke 9:1017~1025
Towfighi A / 2017 / Poststroke depression : a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 48:e30~e43
Kim JS / 2000 / Poststroke depression and emotional incontinence : correlation with lesion location / Neurology 54:1805~1810
Jong S. Kim / 2016 / Post-stroke Mood and Emotional Disturbances: Pharmacological Therapy Based on Mechanisms / 대한뇌졸중학회지 18(3):244~255
Hackett ML / 2014 / Part I : frequency of depression after stroke : an updated systematic review and meta-analysis of observational studies / Int J Stroke 9:1017~1025
Towfighi A / 2017 / Poststroke depression : a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 48:e30~e43
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