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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 213 - 213 (1page)
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Tumor development is a Darwinian evolutionary process of cancer subclones harboring driver gene mutations which dictate the cancer immune microenvironment. However, in gastric cancer, the driver gene mutations leading to immune evasion and tumor development have not been investigated yet. Thus, we performed in vivo CRISPR-Cas9-based knockout screening of candidate driver genes for gastric cancer development in immunocompetent mice. We used a genetic model of mouse gastric organoid lacking p53 (encoded by Trp53) and/or E-cadherin (encoded by Cdh1). We functionally screened 20 candidate genes using the mouse gastric organoids by transplanting pooled knockout organoids into subcutaneous tissues of mice to study clonal advantages in the context of a complex process of tumor deve ... 전체 초록 보기
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