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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 210 - 210 (1page)
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Activated B cells in the germinal center (GC) undergo clonal expansion along with immunoglobulin isotype switching and affinity maturation, leading to differentiation into plasma cells that produce appropriate humoral immunity against invading pathogen. Although PI3K/mTOR signaling is indispensable for survival and proliferation of B cells, little is known about how this signaling pathway integrates environmental milieu within the GCs to regulate GC reactions and to yield plasma cells. In this study, we dissected the impact of PI3K/mTOR signaling pathway on antibody responses by combination of the inducible deletion of Pten (a PI3K-antagonistic lipid phosphatase), Raptor (a subunit of mTORC1), and Rictor (a subunit of mTORC2). Rag2-/- mice were reconstituted with naïve B cells isolated from the inducible KO mice along with normal CD4 T cells and then immunized with NP-ovalbumin. Mice that received Pten depleted B cells exhibited impaired class switching to IgG1 and production of high affinity antibodies against the NP antige ... 전체 초록 보기
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