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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 183 - 183 (1page)
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Ricin is a water soluble glycoprotein extracted from the seeds of the castor oil plant which is highly toxic and has been used for assassination. Ricin is toxic by irreversibly hydrolysis of adenine in eukaryotic 28S ribosomal RNA which is involved in protein synthesis. In this study, we evaluated efficacy of the ricin vaccine which is under development according to adjuvants and adjuvants combination. When the R51 ricin vaccine was administered in ICR mouse in dose of 1 μg/head mixed with aluminum hydroxide, 100% survival rate was observed against 20 x LD50 ricin toxin. However, when TLR agonist, such as flagellin, CpG oligodeoxynucleotide or lipopolysaccharide, was ... 전체 초록 보기
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