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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 163 - 163 (1page)
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Rheumatoid arthritis (RA) is a chronic inflammatory disorders characterized by progressive joint destruction. The green-lipped mussels (GLM) are known to have chondro-modulator and anti-inflammatory properties, but studies on the action mechanism of GLM for the improvement of RA are still insufficient. To investigate the roles of GLM on the pathogenesis of RA, we examined the effects of GLM in collagen-induced arthritis (CIA) mice and peripheral blood mononuclear cells (PBMCs) and fibroblast-like synoviocytes (FLSs) from patients with RA. Application of GLM attenuated the arthritic severity and histologic phenotypes in CIA mice than Methotrexate-treated CIA mice. Numbers of inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-17 -producing cells decreased in the ankle ... 전체 초록 보기
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