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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 97 - 97 (1page)
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Interaction between intestinal commensal bacteria and the host exerts major influence on the organismal homeostasis and disease pathogenesis. In cancer, certain commensal bacteria can directly trigger tumorigenesis and different types of tumor tissues have been shown to harbor several bacteria species inside. On the other hand, intestinal bacteria composition is a key factor determining the effectiveness of cancer treatment such as chemotherapy, radiotherapy, and immunotherapy. Especially, responsiveness to immune checkpoint inhibitors critically depends on the intestinal microbiota and currently several clinical trials are underway to enhance therapeutic efficacy of anti- PD-1 or anti-PD-L1 antibodies by administering a single or a mixture of specific intestinal bacteria species or even by transplanting fecal material collected from cancer survivors who benefited from those immune checkpoint therapeutics. Despite the^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10617878');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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