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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 92 - 92 (1page)
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The human endometrium undergoes extensive remodeling that is unparalleled in any other adult organ. It accomplishes 400 to 500 monthly cycles of morphological and functional change during a women’s reproductive life without leaving any scars. Asherman’s syndrome (AS) is characterized by intrauterine adhesions or fibrosis resulting from scarring inside the endometrium, where endometrial stem/progenitor cells are believed to reside. AS is often associated with menstrual disturbances, infertility, and recurrent miscarriage.
Although mesenchymal stem cells (MSCs) show therapeutic promise for the treatment of AS, the molecular mechanisms underlying its pathophysiology remain unclear. We established a mouse model of AS that suffers from extensive fibrosis, oligo/amenorrhea, and infertility, as in human patients with AS. In mice with AS, embryo implantation is aberrantly deferred, which leads to intrauterine growth restriction followed by no delivery at term. Intrauterine delivery of various MSCs, such as human perivascular ... 전체 초록 보기
Although mesenchymal stem cells (MSCs) show therapeutic promise for the treatment of AS, the molecular mechanisms underlying its pathophysiology remain unclear. We established a mouse model of AS that suffers from extensive fibrosis, oligo/amenorrhea, and infertility, as in human patients with AS. In mice with AS, embryo implantation is aberrantly deferred, which leads to intrauterine growth restriction followed by no delivery at term. Intrauterine delivery of various MSCs, such as human perivascular ... 전체 초록 보기
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