지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 167 - 174 (8page)
- DOI
- 10.3349/ymj.2022.0342
이용수
초록· 키워드
오류제보하기
Purpose: There are no effective treatment methods with which to control complications of radiation proctitis with fistula or re current bleeding following radiation treatment for prostate, cervical, or rectal cancer. Mesenchymal stem cells (MSCs) can induce immune modification, resulting in tissue repair and regeneration. Therefore, we used a rat model of radiation-induced proctitis and observed the effects of using human placenta-derived (PD) and adipose tissue-derived (AD) MSCs.
Materials and Methods: Female Sprague Dawley rats were irradiated at the pelvic area with 25 Gy. We injected 1×106 cells of hu man PD-MSCs, human AD-MSCs, human foreskin fibroblasts, and control media into the rectal submucosa following irradia tion. We sacrificed rats for pathologic evaluation.
Results: Fibrosis on the rectum was reduced in both MSC groups, compared to the control group. Mucosal Ki-67 indices of both MSC injected groups were higher than those in the control group. Although caspase-3 positive cells in the mucosa gradually in creased and decreased in the control group, those in both MSC injected groups increased rapidly and decreased thereafter.
Conclusion: We demonstrated the effects of regional MSC injection treatment for radiation-induced proctitis in rats. MSC injec tion reduced fibrosis and increased proliferation in rat mucosa. Human AD-MSCs and PD-MSCs had similar effectiveness.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dose- and sex-dependent effects on umbilical cord-derived mesenchymal stem cell efficacy in regeneration of a full- thickness tendon defect in a rat model
대한견주관절의학회지
2025 .03
-
The advantages and limitations of mesenchymal stem cells in clinical application for treating human diseases
Osteoporosis and Sarcopenia
2018 .01
-
Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
생체재료학회지
2023 .03
-
The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats
International Neurourology Journal
2018 .01
-
Isolation and characterization of deer-derived mesenchymal stem cells
예방수의학회지
2019 .01
-
Comparison of the characteristics of canine adipose tissue-derived mesenchymal stem cells extracted from different sites and at different passage numbers
Journal of Veterinary Science
2018 .01
-
Establishment of bovine tongue epithelium-derived mesenchymal stem cells
예방수의학회지
2017 .09
-
Regulatory Dendritic Cells Induced by Mesenchymal Stem Cells Ameliorate Dextran Sodium Sulfate-Induced Chronic Colitis in Mice
Gut and Liver
2018 .01
-
Comparison of characteristics of mesenchymal stem cells from bovine
예방수의학회지
2021 .01
-
Comparative characteristic study from bone marrow-derived mesenchymal stem cells
Journal of Veterinary Science
2021 .11
-
Advanced Research on Stem Cell Therapy for Hepatic Diseases: Potential Implications of a Placenta-derived Mesenchymal Stem Cell-based Strategy
Hanyang Medical Reviews
2015 .01
-
The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema
Tuberculosis and Respiratory Diseases
2015 .01
-
Immunomodulatory Function of Mesenchymal Stem Cells for Rheumatoid Arthritis
대한류마티스학회지
2016 .01
-
Anti-inflammatory effects of equine adipose-derived mesenchymal stem cells for bone fracture in thoroughbred racehorses
예방수의학회지
2015 .09
-
Characteristics of mesenchymal stem cells derived from different tissues of goat
예방수의학회지
2019 .01
-
High-glutathione mesenchymal stem cells isolated using the FreSHtracer probe enhance cartilage regeneration in a rabbit chondral defect model
생체재료학회지
2023 .03
-
Adipose tissue-derived mesenchymal stromal cells for treating chronic kidney disease: A pilot study assessing safety and clinical feasibility
Kidney Research and Clinical Practice
2019 .01
-
Scaffold-based synergistic enhancement of stem cell effects for therapeutic angiogenesis in critical limb ischemia: an experimental animal study
Annals of Surgical Treatment and Research
2024 .07
-
Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells
Maxillofacial Plastic Reconstructive Surgery
2017 .03
-
Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4+CD25+ FoxP3+ Regulatory T-Cells and Induced by TGF-β1 and IL-10
Yonsei Medical Journal
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0