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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 91 - 91 (1page)
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Genomic imprinting regulates parental allele-specific gene expression in mammals. Since the first identification of imprinted genes over 30 years ago, germline differential DNA methylation has been the only known primary epigenetic mark that governs genomic imprinting. A few years ago, we discovered that histone H3 lysine 27 trimethylation (H3K27me3), deposited by polycomb repressive complex 2 (PRC2), is transmitted from oocytes to embryos and regulates DNA methylation-independent (non-canonical) imprinting in mice. How H3K27me3 is properly established during oogenesis and inherited by embryos remains largely unknown. In this talk, I will introduce the role ... 전체 초록 보기
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