지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The resistance of currently used antibiotics has emerged the necessity of a new one. Delafloxacin is a new fluoroquinolone derivative that is distinct from its competitors. Among the fluoroquinolone antibiotics, delafloxacin shows a broad spectrum of efficacy against a variety of microorganisms. Delafloxacin has large treatment potential for complicated intra-abdominal infections, acute bacterial exacerbation of chronic bronchitis (ABECB), urogenital infections, etc. Delafloxacin exhibits a potent efficacy against methicillin-resistant Staphylococcu aureus (MRSA), Pseudomonas aeruginosa, Enterococcus faecalis, S. aureus, and Enterobacteriaceae compared to levofloxacin and moxifloxacin. The potency of delafloxacin increases in acidic environment whereas other fluoroquinolones exhibit decreased potency in acidic media. The probability of antibiotic resistance cases is comparatively low for delafloxacin because its dual affinity for both DNA gyrase and topoisomerase IV is nearly equal. Delafloxacin usually eliminates via renal either as glucuronide conjugates or intact drugs. Dosage adjustment is necessary for severe renal impairment patients but not necessary for hepatic or mild to moderate renal impairment patients. The commonly observed adverse effects of delafloxacin are diarrhea, nausea, headache, vomiting, and transaminase elevations. Other fluoroquinolones have been reported to cause phototoxicity but it was not found in delafloxacin treatment. The overall information showed delafloxacin a superior antibacterial agent over other fluoroquinolones. In this review, we pointed out the upcoming use of delafloxacin for treating bacterial infections.
목차
Comparative Activity of Delafloxacin with Other Fluoroquinolones
Chemistry and Structural Description
Mechanism of Action
Pharmacokinetics and Pharmacodynamics
Doses and Precautions
Adverse Effects
Resistance and Treatment Failure
Conclusion
References
참고문헌 (49)
참고문헌 신청
Adler A, Chaudhry S, and Goldberg T. 2018. BaxdelaTM (Delafloxacin): a novel fluoroquinolone for the treatment of acute bacterial skin and skin structure infections. P. T. 43, 662–666.
Alam P, Iqbal M, Ezzeldin E, Khalil NY, Foudah AI, Alqarni MH, and Shakeel F. 2020. Simple and accurate HPTLC-densitometric method for quantification of delafloxacin (a novel fluoroquinolone antibiotic) in plasma samples: Application to pharmacokinetic study in rats. Antibiotics 9, 134.
Anwer M, Iqbal M, Muharram MM, Mohammad M, Ezzeldin E, Aldawsari MF, Alalaiwe A, and Imam F. 2020. Development of lipomer nanoparticles for the enhancement of drug release, anti-microbial activity and bioavailability of delafloxacin. Pharmaceutics 12, 252.
Bassetti M, Righi E, Pecori D, and Tillotson G. 2018. Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering. Future Microbiol. 13, 1081–1094.
Boyanova L, Markovska R, Medeiros J, Gergova G, and Mitov I. 2020a. Delafloxacin against Helicobacter pylori, a potential option for improving eradication success? Diagn. Microbiol. Infect. Dis. 96, 114980.
Alam P, Iqbal M, Ezzeldin E, Khalil NY, Foudah AI, Alqarni MH, and Shakeel F. 2020. Simple and accurate HPTLC-densitometric method for quantification of delafloxacin (a novel fluoroquinolone antibiotic) in plasma samples: Application to pharmacokinetic study in rats. Antibiotics 9, 134.
Anwer M, Iqbal M, Muharram MM, Mohammad M, Ezzeldin E, Aldawsari MF, Alalaiwe A, and Imam F. 2020. Development of lipomer nanoparticles for the enhancement of drug release, anti-microbial activity and bioavailability of delafloxacin. Pharmaceutics 12, 252.
Bassetti M, Righi E, Pecori D, and Tillotson G. 2018. Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering. Future Microbiol. 13, 1081–1094.
Boyanova L, Markovska R, Medeiros J, Gergova G, and Mitov I. 2020a. Delafloxacin against Helicobacter pylori, a potential option for improving eradication success? Diagn. Microbiol. Infect. Dis. 96, 114980.
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