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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 182 - 186 (5page)
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초록· 키워드
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Parkinson disease (PD) is becoming one of the most neurodegenerative disorder worldwide. The deposited aggregates have been connected in the pathophysiology of PD, which are degraded either by ubiquitin-proteasomal system (UPS) or autophagy-lysosomal pathway (ALP). Leucin-rich repeat kinase 2 (LRRK2), one of the neurodegenerative proteins of PD is also stringently controlled by both UPS and ALP degradation as well. However, the polyubiquitination pattern of LRRK2 aggregates is largely unknown. Here, we found that K63-linked polyubiquitinations of G2019S mutant, most familial variant for PD, is highly enhanced compared to those of wild type LRRK2 (WT). In addition, in the presence of overexpressed p62/SQSTM-1, ubiquitination of LRRK2 WT or D1994A was reduced, whereas G2019S mutant was not diminished significantly. Therefore, we propose that degradation of G2019S via UPS is more involved with K63-linked ubiquitination than K48-linked ubiquitination, and overexpressed p62/SQSTM-1 does not enhance degradative effect on G2019S variant.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Alessi DR / 2018 / LRRK2 kinase in Parkinson's disease / Science 360:36~37
Bonifati V / 2003 / Mutations in the DJ-1gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
Clark LN / 2005 / Pilot association study of the beta-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity / Mov Disord 20:100~103
Cookson MR / 2010 / The role of leucine-rich repeat kinase 2(LRRK2)in Parkinson's disease / Nat Rev Neurosci 11:791~797
Hampton RY / 2002 / ER-associated degradation in protein quality control and cellular regulation / Curr Opin Cell Biol 14:476~482
Bonifati V / 2003 / Mutations in the DJ-1gene associated with autosomal recessive early-onset parkinsonism / Science 299:256~259
Clark LN / 2005 / Pilot association study of the beta-glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicity / Mov Disord 20:100~103
Cookson MR / 2010 / The role of leucine-rich repeat kinase 2(LRRK2)in Parkinson's disease / Nat Rev Neurosci 11:791~797
Hampton RY / 2002 / ER-associated degradation in protein quality control and cellular regulation / Curr Opin Cell Biol 14:476~482
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