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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 111 - 120 (10page)
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초록· 키워드
오류제보하기
Asbestos products had been widely used until 2007 in Korea since the 1930s. A total ban on their production and applications has been imposed because of the toxic effect of asbestos fibers on the human health. The inhaled asbestos fibers increase reactive oxygen species and inflammatory reactions in the respiratory airway including the alveolar sac, resulting in DNA damages and secretion of several inflammatory cytokines or chemokines. These paracrine communications promote the proliferation of fibroblasts and the synthesis of collagen fibers, thereby depositing them into the extracellular matrix at the interstitial space of alveoli. The fibrotic tissue hindered the gas exchange in the alveolus. This reviews describes not only the cytotoxic effects of asbestos fibers with different physical or chemical characteristics but also the interaction of cells that make up the respiratory airway to understand the molecular or cellular mechanisms of asbestos fiber-induced toxicity. In addition, we propose a pulmonary toxicity research technique based on the mini-lung that can mimic human respiratory system as an alternative to overcome the limitations of the conventional risk assessment of asbestos fibers.
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REFERENCES
참고문헌 (39)
참고문헌 신청
Barlow CA / 2017 / Asbestos fiber length and its relation to disease risk / Inhal Toxicol 29:541~554
Blázquez-Prieto J / 2021 / Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation / Transl Res 233:104~116
Chapman KE / 2005 / Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells / Am J Physiol Lung Cell Mol Physiol 289:L834~L841
Choi JK / 1998 / The Production, the Use, the Number of Workers and Exposure Levels of Asbestos in Korea / Korean Ind Hyg Assoc J 8:242~253
Duffield JS / 2005 / Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair / J Clin Invest 115:56~65
Blázquez-Prieto J / 2021 / Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation / Transl Res 233:104~116
Chapman KE / 2005 / Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells / Am J Physiol Lung Cell Mol Physiol 289:L834~L841
Choi JK / 1998 / The Production, the Use, the Number of Workers and Exposure Levels of Asbestos in Korea / Korean Ind Hyg Assoc J 8:242~253
Duffield JS / 2005 / Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair / J Clin Invest 115:56~65
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