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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 82 - 83 (2page)
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Tumor-targeted fluorescence imaging has the potential to revolutionize current practice of oncologic surgery by selectively highlighting malignant tissue and normal structures during surgery and other minimal invasive procedures. For the detection of colorectal cancer (CRC) hepatic metastases, the non -targeted dye indocyanine green (ICG) can be used and this is currently standard of care in our medical center. However, for the detection of CRC outside the liver, ICG is not optimal and various targets were explored for real-time tumor visualization by different research groups. Carcinoembryonic antigen (CEA) is overexpressed in the majority of colorectal cancers (CRC) and is a promising target for CRC imaging. Therefore, a dose-escalating study was performed by our group to determine pharmacokinetics (PK) and tolerability of SGM-101, a novel fluorescent anti-CEA monoclonal antibody, and to investigate the feasibility to detect colorectal cancer with fluorescence imaging in real-time. Nine patients with primary and 17 (expansion cohort, recurrent CRC and / or peritoneal carcinomatosis) with recurrent or with peritoneal metastases (scheduled for HIPEC) were included. SGM-101 did not cause any treatment-related adverse events and a dose of 10 mg, administered four days before the surgical procedure, ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-514-001919167