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논문 기본 정보

자료유형
학술저널
저자정보
Yoo-kyoung Shin (Department of Biomedical Science College of Medicine Dankook University Cheonan Korea) 엄주범 (단국대학교)
저널정보
대한의학레이저학회 MEDICAL LASERS Medical Lasers 제10권 제3호
발행연도
2021.9
수록면
123 - 131 (9page)
DOI
10.25289/ML.2021.10.3.123

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초록· 키워드

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Optical imaging modalities with properties of real-time, non-invasive, in vivo, and high resolution for image-guided surgery have been widely studied. In this review, we introduce two optical imaging systems, that could be the core of image-guided surgery and introduce the system configuration, implementation, and operation methods. First, we introduce the optical coherence tomography (OCT) system implemented by our research group. This system is implemented based on a sweptsource, and the system has an axial resolution of 11 μm and a lateral resolution of 22 μm. Second, we introduce a fluorescence imaging system. The fluorescence imaging system was implemented based on the absorption and fluorescence wavelength of indocyanine green (ICG), with a light-emitting diode (LED) light source. To confirm the performance of the two imaging systems, human malignant melanoma cells were injected into BALB/c nude mice to create a xenograft model and using this, OCT images of cancer and pathological slide images were compared. In addition, in a mouse model, an intravenous injection of indocyanine green was used with a fluorescence imaging system to detect real-time images moving along blood vessels and to detect sentinel lymph nodes, which could be very important for cancer staging. Finally, polarization-sensitive OCT to find the boundaries of cancer in real-time and real-time image-guided surgery using a developed contrast agent and fluorescence imaging system were introduced.

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