지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 157 - 165 (9page)
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초록· 키워드
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This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones in young adult rats exposed to caffeine. Exposure to caffeine reduced the size and absolute weight of the testes significantly in immature animals in comparison to control animals, but not in young adult animals exposed to caffeine. In contrast, the adrenal glands were significantly heavier in caffeine-fed young adult rats in comparison to control animals, but not in caffeine-fed immature rats. Our results clearly show that the negative effects of caffeine on the long bones and testes in rats are different according to the age of the rat at the time of exposure, and might therefore be caused by changes to organ sensitivity and metabolic rate at different developmental stages. Although the long bones and testes are more susceptible to caffeine during puberty, caffeine has negative effects on body fat, bone minerals and the adrenal glands when exposure occurs during young adulthood. There is a need, therefore, to educate the public the potential dangers of caffeine consumption during puberty and young adulthood.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Seifert, S.M / 2011 / Health effects of energy drinks on children, adolescents, and young adults / Pediatrics 127:511~528
Ishak, W.W / 2012 / Energy drinks: psychological effects and impact on well-being and quality of life-a literature review / Innov. Clin. Neurosci 9:25~34
Yeh, J.K / 1986 / Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats / J. Bone Miner. Res 1:251~258
유동철 / 2011 / Possible Health Effects of Caffeinated Coffee Consumption on Alzheimer's Disease and Cardiovascular Disease / 한국독성학회지 27(1):7~10
Shin, J / 2015 / High doses of caffeine reduce in vivo osteogenic activity in prepubertal rats / J. Anat 227:10~20
Ishak, W.W / 2012 / Energy drinks: psychological effects and impact on well-being and quality of life-a literature review / Innov. Clin. Neurosci 9:25~34
Yeh, J.K / 1986 / Differential effect of caffeine administration on calcium and vitamin D metabolism in young and adult rats / J. Bone Miner. Res 1:251~258
유동철 / 2011 / Possible Health Effects of Caffeinated Coffee Consumption on Alzheimer's Disease and Cardiovascular Disease / 한국독성학회지 27(1):7~10
Shin, J / 2015 / High doses of caffeine reduce in vivo osteogenic activity in prepubertal rats / J. Anat 227:10~20
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UCI(KEPA) : I410-ECN-0101-2017-513-002409964