지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 74 - 78 (5page)
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초록· 키워드
오류제보하기
Tigecycline is known to form a complex with divalent cations such as Mg<SUP>2+</SUP> and Ca<SUP>2+</SUP>, which is essential for a mode of action of tigecycline. In this study, we investigated the effects of levels of divalent cations on the in vitro antibacterial activity of tigecycline against two strains each of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. When Mg<SUP>2+</SUP> or Ca<SUP>2+</SUP> was added to be tantamount to criteria levels of severe hypermagnesemia or hypercalcemia in Mueller-Hinton II broth, minimum inhibitory concentrations were increased 2- to 4-fold in all strains. In media containing high concentrations of Mg<SUP>2+</SUP> or Ca<SUP>2+</SUP>, bacterial survival rates increased significantly after 24-hour exposure to tigecycline for all strains except one K. pneumoniae strain. Thus, levels of divalent cations in extracellular condition might affect tigecycline activity. While testing on humans is still required, our results suggest that caution should be exercised when using tigecycline to treat infected patients with hypermagnesemia and hypercalcemia.
목차
NTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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