지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 67 - 67 (1page)
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Background : Mechanism related with inflammation is one of the cause of Alzheimer's disease (AD), a major form of dimentia. Dendranthema boreale (Makino) Ling ex Kitam. (DB), a plant of Asteraceae, was selected among several plant materials from in vitro assay. In the study, DB extract was evaluated on its potential as memory enhancing property through in vivo assay.
Methods and Results : DB extracts prepared with the mixed solvent of ethanol and water was tested the inhibition activity on nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-α) level and the effect on cell viability in lipopolysaccharide (LPS)-treated BV2 murine microglia cells. As in vivo experiment, rats were administered with the diets including DB extract (0.07% and 0.14%) and induced memory dysfunction with scopolamine (1 ㎎/㎏/day, intraperitoneally) injection for 21 day. Learning- and memory-improving potential of rats were observed via the behavior test in Y-maze and passive avoidance test (PAT). Biomarkers related with cognition were analyzed in the hippocampal tissue and t ... 전체 초록 보기
Methods and Results : DB extracts prepared with the mixed solvent of ethanol and water was tested the inhibition activity on nitric oxide (NO) production, tumor necrosis factor-alpha (TNF-α) level and the effect on cell viability in lipopolysaccharide (LPS)-treated BV2 murine microglia cells. As in vivo experiment, rats were administered with the diets including DB extract (0.07% and 0.14%) and induced memory dysfunction with scopolamine (1 ㎎/㎏/day, intraperitoneally) injection for 21 day. Learning- and memory-improving potential of rats were observed via the behavior test in Y-maze and passive avoidance test (PAT). Biomarkers related with cognition were analyzed in the hippocampal tissue and t ... 전체 초록 보기
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