Lymphopenia following pancreaticoduodenectomy is associated with pancreatic fistula formation

Joshua T. Cohen; Kevin P. Charpentier; Thomas J. Miner; William G. Cioffi; Rachel E. Beard

추천

검색

질문

자료유형: 학술저널

저자정보: Joshua T. Cohen (Warren Alpert Medical School of Brown University) Kevin P. Charpentier (Warren Alpert Medical School of Brown University) Thomas J. Miner (Warren Alpert Medical School of Brown University) William G. Cioffi (Warren Alpert Medical School of Brown University) Rachel E. Beard (Warren Alpert Medical School of Brown University)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제25권 제2호

발행연도: 2021.5

수록면: 242 - 250 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Backgrounds/Aims: Post-operative pancreatic fistulas (POPF) are a major source of morbidity following pancreaticoduodenectomy (PD). This study aims to investigate if persistent lymphopenia, a known marker of sepsis, can act as an additional marker of POPF with clinical implications that could help direct drain management. Methods: A retrospective chart review of all patients who underwent PD in a single hospital network from 2008 to 2018. Persistent lymphopenia was defined as lymphopenia beyond post-operative day #3. Results: Of the 201 patients who underwent PD during the study period 161 patients had relevant laboratory data, 81 of whom had persistent lymphopenia. 17 patients with persistent lymphopenia went on to develop a POPF, compared to 7 patients without. Persistent lymphopenia had a negative predictive value of 91.3%. Multivariate analysis revealed only persistent lymphopenia as being independently associated with POPF (HR 2.57, 95% CI 1.07-6.643, p=0.039). Patients with persistent lymphopenia were more likely to have a complication requiring intervention (56.8% vs 35.0%, p＜0.001). Conclusions: Persistent lymphopenia is a readily available early marker of POPF that holds the potential to identify clinically relevant POPF in patients where no surgical drain is present, and to act as an adjunct of drain amylase helping to guide drain management.

#Lymphopenia #Post-operative pancreatic fistula #Pancreaticoduodenectomy

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!