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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 65 - 65 (1page)
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Non-alcoholic fatty liver disease (NAFLD) is tightly associated with ‘Metabolic Syndrome’, and both are rapidly becoming a pandemic. NAFLD shows a spectrum of liver pathology that mimics alcohol-induced fatty liver damage. A subset of individuals with NAFLD develops non-alcoholic steatohepatitis (NASH), some of which progresses to cirrhosis and/or liver cancer. Importantly, this pathophysiologic continuum of NAFLD begins with steatosis; i.e., accumulation of triglyceride (TG). Despite many studies discovered gene regulatory program directing steatosis, the epigenetic mechanisms that drive steatosis are still ill-defined. Transcriptional coactivator complex named MLL4-complex (herein referred to as MLL4-C) contains the histone H3-lysine 4-methyl ... 전체 초록 보기
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