지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The objective of this study was to investigate urinary cut-off concentrations of quetiapine and risperidone for distinction between normal and abnormal/non-takers who were being placed on probation. Liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was employed for determination of antipsychotic drugs in urine from mentally disordered probationers. The optimal cut-off values of antipsychotic drugs were calculated using receiver operating characteristic (ROC) curve analysis. The sensitivity and specificity of the method for the detection of antipsychotic drugs in urine were subsequently evaluated. The area under the ROC curve (AUC) was 0.927 for norquetiapine and 0.791 for 9-hydroxyrisperidone, respectively. These antipsychotic drugs are classified readily in the ROC curve analysis. The cut-off values for distinguishing regular and irregular/non-takers were 39.1 ng/mL for norquetiapine and 67.9 ng/mL for 9-hydroxyrisperidone, respectively. The results of this study suggest the cut-off values of quetiapine and risperidone were highly useful to distinguish regular takers from irregular/non-takers.
목차
Abstract
1. Introduction
2. Experiment
3. Results and Discussion
4. Conclusions
References
참고문헌 (20)
참고문헌 신청
Supreme Prosecutors' Office, ‘2019 Analytical Statistics on Crime’, Seoul, Korea, 2019.
S. I. Jang, Regal Theory & Practice Rev., 4, 103-128 (2016).
B. S. Kim, Law Rev., 60. 195-217 (2019).
J. H. Cho, S. H. Kang, S. J. Lee, J. G. Kim and M. J. Joo, J. Korean Soc. Biol. Ther. Psychiatry, 10, 172-183 (2004).
H. A. Pincus, Schizophr. Bull., 36, 109-111 (2010).
S. I. Jang, Regal Theory & Practice Rev., 4, 103-128 (2016).
B. S. Kim, Law Rev., 60. 195-217 (2019).
J. H. Cho, S. H. Kang, S. J. Lee, J. G. Kim and M. J. Joo, J. Korean Soc. Biol. Ther. Psychiatry, 10, 172-183 (2004).
H. A. Pincus, Schizophr. Bull., 36, 109-111 (2010).
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