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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 93 - 93 (1page)
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One of the components in Gastrodia elata Blume (GEB) extract is p-hydroxybenzyl alcohol, which inhibits reactive oxygen species (ROS) production, exhibits anti-inflammatory activity, and downregulates the free radical and lipid peroxide levels. Vancomycin hydrochloride (VAN), a glycopeptide antibiotic, is associated with several side effects, including nephrotoxicity. This study investigated the preventive effects of GEB extract on vancomycin-induced acute kidney injury in rats. Five-week-old male Sprague-Dawley rats were randomly divided into the following three groups: control (CON) group, orally administered distilled water (10 mL/kg BW); vancomycin (VAN) group, orally administered distilled water (10 mL/kg BW); Gastrodia elata Blume (GEB) group, orally administered GEB extract (10 mL/kg BW). The treatment period was 14 days. The VAN and GEB groups were intraperitoneally administered VAN (400 mg/kg BW) after oral administration for the last 3 days of the 14-day treatment period. The rats were anesthetized using isoflurane and sacrificed. The kidney weight and the serum levels of blood urea nitrogen and ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-528-001569781