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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 193 - 196 (4page)
- DOI
- https://doi.org/10.13041/jpvm.2017.41.4.193
이용수
초록· 키워드
오류제보하기
This study examined the acute toxicity of Super-Neophensan containing florfenicol and acetaminophen in male and female Sprague-Dawley rats. Rats were orally administered the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for the single-dose toxicity test. BW changes in all treated groups were not significantly different to those in the control treated with saline. In hematological and blood biochemical analyses, all parameters were unaffected by the drug. In the same way, there were no significant differences between all treated groups and the control group in terms of markers for liver and kidney functions. As no adverse effects were observed with the drug in the single-dose oral toxicity test, even at the highest concentration of the drug, the lethal dose 50 (LD50) of Super-Neophensan is estimated to be greater than 2,000 mg/kg BW.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
차춘남 / 2017 / Effects of dietary acetaminophen and vitamin C supplement on serum cortisol and tumor necrosis factor-alpha concentrations in pigs vaccinated with foot-and-mouth disease vaccine / 대한수의학회지 57(3):197~200
조주현 / 2011 / Single- and repeated-dose toxicities of aloe fermentation products in rats / Laboratory Animal Research 27(3):235~244
Cooper TE / 2017 / Paracetamol (acetaminophen)for chronic non-cancer pain in children and adolescents / Cochrane Database Syst Rev 8:CD012539
Crawley B / 2008 / Acetaminophen prevents hyperalgesia in central pain cascade / Neurosci Lett 442:50~53
Del Pozo Sacristán R / 2012 / Efficacy of florfenicol injection in the treatment of Mycoplasma hyopneumoniae induced respiratory disease in pigs / Vet J 194:420~422
조주현 / 2011 / Single- and repeated-dose toxicities of aloe fermentation products in rats / Laboratory Animal Research 27(3):235~244
Cooper TE / 2017 / Paracetamol (acetaminophen)for chronic non-cancer pain in children and adolescents / Cochrane Database Syst Rev 8:CD012539
Crawley B / 2008 / Acetaminophen prevents hyperalgesia in central pain cascade / Neurosci Lett 442:50~53
Del Pozo Sacristán R / 2012 / Efficacy of florfenicol injection in the treatment of Mycoplasma hyopneumoniae induced respiratory disease in pigs / Vet J 194:420~422
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