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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 99 - 107 (9page)
이용수
이 논문의 연구 히스토리 (5)
2021
Inhibition of lipopolysaccharide-induced neuroinflammatory responses by Carpomitra costata extract in BV2 microglia through the inactivation of NF-κB associated with the blockade of the TLR4 pathway and ROS generation
Yung Hyun Choi
,
Cheol Pa
,
k
외 3명
한국수산과학회 양식분과 학술대회
2021.04
학술대회자료
Carpomitra costata extract attanuates interleukin-1β-induced inflammatory response in SW1353 human chondrocytes through suppressing NF-κB signaling pathway
Yung Hyun Choi
,
Cheol Pa
,
k
한국수산과학회 양식분과 학술대회
2021.04
학술대회자료
2018
Carpomitra costata Alleviates Lipopolysaccharideinduced Inflammatory Responses in BV2 Microglia through the Inactivation of NF-κB and TLR4 Pathways
Yung Hyun Choi
,
Cheol Pa
,
k
외 4명
한국식품영양과학회 학술대회발표집
2018.10
학술대회자료
Suppression of interleukin-1β-induced inflammatory responses by ethanol extract of Carpomitra costata in SW1353 human chondrocytes through suppressing NF-kB signaling pathway
Yung Hyun Choi
,
Jin-Woo Jeong
,
Cheol Pa
외 8명
한국수산과학회 양식분과 학술대회
2018.05
학술대회자료
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초록· 키워드
오류제보하기
Osteoarthritis (OA) is an inflammatory degenerative joint disease that is accompanied by irreversible joint cartilage destruction. Recently, the antioxidant effects of Carpomitra costata, which is a type of brown algae, have been reported, but their effects on OA have not been investigated. In this study, the anti-osteoarthritic effect of the ethanol extract of C. costata (EECC) on SW1353 human chondrocytes was studied. Results showed that EECC significantly attenuated the interleukin-1β (IL-1β)-induced release of pro-inflammatory mediators, including prostaglandin E2 and nitric oxide (NO), as well as expressions of cyclo-oxygenase-2 and inducible NO synthase. EECC also inhibited the IL-1β-induced expressions of matrix metalloproteinase-1, -3, and -13 in SW1353 chondrocytes, which reduced their extracellular secretion. In addition, the oxidative stress induced by IL-1β was confirmed to be blocked by EECC due to the inhibition of reactive oxygen species generation. Moreover, EECC suppressed IL-1β-mediated translocation of nuclear factor-kappa B (NF-κB) from cytosol into the nucleus and the degradation of IκB-α, which indicates that EECC exhibits anti-inflammatory effects by inhibiting the NF-κB signaling pathway. These results are the first to demonstrate the anti-inflammatory activities of C. costata extracts in chondrocytes, thus suggesting that this algae extract may be used in the treatment of OA.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (27)
참고문헌 신청
Brittberg, M. / 2016 / Cartilage repair in the degenerative ageing knee / Acta. Orthop 87:S26~S38
Andriacchi, T. P. / 2015 / A systems view of risk factors for knee osteo-arthritis reveals insights into the pathogenesis of the disease / Ann. Biomed. Eng 43:376~387
손영옥 / 2018 / Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis / BMB Reports 51(4):165~166
Hochberg, M. / 2013 / Symptom and structure modification in osteoarthritis with pharmaceutical-grade chon-droitin sulfate : what's the evidence? Curr / Med. Res. Opin 29:259~267
Martel-Pelletier, J. / 2008 / Cartilage in normal and osteoarthritis conditions / Best Pract. Res. Clin. Rheumatol 22:351~384
Andriacchi, T. P. / 2015 / A systems view of risk factors for knee osteo-arthritis reveals insights into the pathogenesis of the disease / Ann. Biomed. Eng 43:376~387
손영옥 / 2018 / Estrogen-related receptor γ is a novel catabolic regulator of osteoarthritis pathogenesis / BMB Reports 51(4):165~166
Hochberg, M. / 2013 / Symptom and structure modification in osteoarthritis with pharmaceutical-grade chon-droitin sulfate : what's the evidence? Curr / Med. Res. Opin 29:259~267
Martel-Pelletier, J. / 2008 / Cartilage in normal and osteoarthritis conditions / Best Pract. Res. Clin. Rheumatol 22:351~384
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Carpomitra costata Extract Alleviates Lipopolysaccharide-induced Neuroinflammatory Responses in BV2 Microglia through the Inactivation of NF-κB Associated with the Blockade of the TLR4 Pathway and ROS Generation
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Croton hirtus L'Hér Extract Prevents Inflammation in RAW264.7 Macrophages Via Inhibition of NF-κB Signaling Pathway
Journal of Microbiology and Biotechnology
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Anti-Inflammatory Activity of Oligomeric Proanthocyanidins Via Inhibition of NF-ΚB and MAPK in LPS-Stimulated MAC-T Cells
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Ampelopsin alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats
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Anti-inflammatory effects of rutin in lipopolysaccharide-stimulated canine macrophage cells
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Inhibition of TNFα-induced interleukin-6 gene expression by barley (Hordeum vulgare) ethanol extract in BV-2 microglia
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A Novel Synthetic Compound, YH-1118, Inhibited LPS-Induced Inflammatory Response by Suppressing IκB Kinase/NF-κB Pathway in Raw 264.7 Cells
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Beneficial Therapy with Natural Anti-Inflammatory Agents and Supplements
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UCI(KEPA) : I410-ECN-0101-2021-472-001410948