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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 557 - 566 (10page)
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Background Inflammation in the central nervous system is closely associated with pathological neurodegenerative diseases as well as psychiatric disorders. Prolonged activation of microglia can produce many inflammatory mediators, which may result in pathological neurotoxic side effects. Interleukin (IL)-6 serves as a hallmark of the injured brain. Objective Whole grains are known to contain many bioactive components. However, little information is available about anti-neuroinflammatory effects of grains in the CNS. This study aims to investigate the effect of Hordeum vulgare ethanol extract (HVE) on the suppression of IL-6 expression in BV2 microglia. Methods Inhibitory effects of HVE on IL-6 expression were analyzed by immunoblot anaysis, immunofluoresce microscopic analysis, reverse transcription-polymerase chain reaction, and luciferase promoter reporter assay. Results HVE inhibited TNFα-induced phosphorylation of IKKα/β, IκB, and p65/RelA NF-κB. TNFα-induced IL-6 mRNA expression and promoter activity were reduced by HVE. Point mutation of NF-κB-binding site within the IL-6 gene promoter abolished TNFα-induced reporter activity, whereas exogenous expression of p65 NF-κB enhanced IL-6 promoter activity. Conclusion NF-κB-binding site within the IL-6 promoter region is a HVE target element involved in the inhibition of TNFα- induced IL-6 gene transcription. HVE inhibits TNFα-induced IL-6 expression via suppression of NF-κB signaling in BV2 microglial cells.
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참고문헌 (45)
참고문헌 신청
Baccam M / 2003 / CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes : involvement of NF-kappa B, AP-1, and C/EBP / J Immunol 170:3099~3108
Balkwill F / 2009 / Tumour necrosis factor and cancer / Nat Rev Cancer 9:361~371
Barnes PJ / 1997 / Nuclear factor-kappaB : a pivotal transcription factor in chronic inflammatory diseases / N Engl J Med 336:1066~1071
Becher B / 2017 / Cytokine networks in neuroinflammation / Nat Rev Immunol 17:49~59
Bhakar AL / 2002 / Constitutive nuclear factorkappa B activity is required for central neuron survival / J Neurosci 22:8466~8475
Balkwill F / 2009 / Tumour necrosis factor and cancer / Nat Rev Cancer 9:361~371
Barnes PJ / 1997 / Nuclear factor-kappaB : a pivotal transcription factor in chronic inflammatory diseases / N Engl J Med 336:1066~1071
Becher B / 2017 / Cytokine networks in neuroinflammation / Nat Rev Immunol 17:49~59
Bhakar AL / 2002 / Constitutive nuclear factorkappa B activity is required for central neuron survival / J Neurosci 22:8466~8475
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